Flights from Portland to Des Moines (PDX to DSM)

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US$158

6:02pm - 11:17pm
Thu Jul 17th 2025

3h 15m
Portland (PDX) → Des Moines (DSM)

Direct

Thu Jul 17th 2025 Allegiant Air · G4 438 Depart at 6:02pm from Portland (PDX) Fly for 3h 15m Arrive at 11:17pm in Des Moines (DSM)
US$183

6:02pm - 11:17pm
Sun Jul 20th 2025

3h 15m
Portland (PDX) → Des Moines (DSM)

Direct

Sun Jul 20th 2025 Allegiant Air · G4 438 Depart at 6:02pm from Portland (PDX) Fly for 3h 15m Arrive at 11:17pm in Des Moines (DSM)
US$197

4:54pm - 10:09pm
Tue Jul 15th 2025

3h 15m
Portland (PDX) → Des Moines (DSM)

Direct

Tue Jul 15th 2025 Allegiant Air · G4 438 Depart at 4:54pm from Portland (PDX) Fly for 3h 15m Arrive at 10:09pm in Des Moines (DSM)
US$379

12:55pm - 8:15pm
Wed Jul 16th 2025

5h 20m
Portland (PDX) → Des Moines (DSM)

1 Stop

Wed Jul 16th 2025 United Airlines · UA 2254 Depart at 12:55pm from Portland (PDX) Fly for 2h 40m Arrive at 4:35pm in Denver (DEN)

Layover in Denver for 0h 55m

Wed Jul 16th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$379

8:50am - 4:15pm
Wed Jul 16th 2025

5h 25m
Portland (PDX) → Des Moines (DSM)

1 Stop

Wed Jul 16th 2025 United Airlines · UA 2375 Depart at 8:50am from Portland (PDX) Fly for 2h 35m Arrive at 12:25pm in Denver (DEN)

Layover in Denver for 1h 5m

Wed Jul 16th 2025 United Airlines · UA 2265 Depart at 1:30pm from Denver (DEN) Fly for 1h 45m Arrive at 4:15pm in Des Moines (DSM)
US$379

4:16pm - 11:59pm
Wed Jul 16th 2025

5h 43m
Portland (PDX) → Des Moines (DSM)

1 Stop

Wed Jul 16th 2025 United Airlines · UA 2190 Depart at 4:16pm from Portland (PDX) Fly for 2h 39m Arrive at 7:55pm in Denver (DEN)

Layover in Denver for 1h 8m

Wed Jul 16th 2025 United Airlines · UA 5954 Depart at 9:03pm from Denver (DEN) Fly for 1h 56m Arrive at 11:59pm in Des Moines (DSM)
US$379

10:55am - 8:15pm
Wed Jul 16th 2025

7h 20m
Portland (PDX) → Des Moines (DSM)

1 Stop

Wed Jul 16th 2025 United Airlines · UA 1027 Depart at 10:55am from Portland (PDX) Fly for 2h 35m Arrive at 2:30pm in Denver (DEN)

Layover in Denver for 3h 0m

Wed Jul 16th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$379

12:54pm - 10:17pm
Wed Jul 16th 2025

7h 23m
Portland (PDX) → Des Moines (DSM)

1 Stop

Wed Jul 16th 2025 United Airlines · UA 1794 Depart at 12:54pm from Portland (PDX) Fly for 4h 16m Arrive at 7:10pm in Houston (IAH)

Layover in Houston for 0h 45m

Wed Jul 16th 2025 United Airlines · UA 1780 Depart at 7:55pm from Houston (IAH) Fly for 2h 22m Arrive at 10:17pm in Des Moines (DSM)
US$379

10:48am - 9:47pm
Wed Jul 16th 2025

8h 59m
Portland (PDX) → Des Moines (DSM)

1 Stop

Wed Jul 16th 2025 United Airlines · UA 534 Depart at 10:48am from Portland (PDX) Fly for 4h 8m Arrive at 4:56pm in Chicago (ORD)

Layover in Chicago for 3h 24m

Wed Jul 16th 2025 United Airlines · UA 1531 Depart at 8:20pm from Chicago (ORD) Fly for 1h 27m Arrive at 9:47pm in Des Moines (DSM)
US$380

8:50am - 4:15pm
Tue Jul 15th 2025

5h 25m
Portland (PDX) → Des Moines (DSM)

1 Stop

Tue Jul 15th 2025 United Airlines · UA 2375 Depart at 8:50am from Portland (PDX) Fly for 2h 35m Arrive at 12:25pm in Denver (DEN)

Layover in Denver for 1h 5m

Tue Jul 15th 2025 United Airlines · UA 2265 Depart at 1:30pm from Denver (DEN) Fly for 1h 45m Arrive at 4:15pm in Des Moines (DSM)
US$380

4:16pm - 11:59pm
Tue Jul 15th 2025

5h 43m
Portland (PDX) → Des Moines (DSM)

1 Stop

Tue Jul 15th 2025 United Airlines · UA 2190 Depart at 4:16pm from Portland (PDX) Fly for 2h 39m Arrive at 7:55pm in Denver (DEN)

Layover in Denver for 1h 8m

Tue Jul 15th 2025 United Airlines · UA 5954 Depart at 9:03pm from Denver (DEN) Fly for 1h 56m Arrive at 11:59pm in Des Moines (DSM)
US$380

4:16pm - 11:59pm
Sat Jul 19th 2025

5h 43m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sat Jul 19th 2025 United Airlines · UA 2190 Depart at 4:16pm from Portland (PDX) Fly for 2h 39m Arrive at 7:55pm in Denver (DEN)

Layover in Denver for 1h 8m

Sat Jul 19th 2025 United Airlines · UA 5954 Depart at 9:03pm from Denver (DEN) Fly for 1h 56m Arrive at 11:59pm in Des Moines (DSM)
US$380

2:12pm - 11:00pm
Tue Jul 15th 2025

6h 48m
Portland (PDX) → Des Moines (DSM)

1 Stop

Tue Jul 15th 2025 United Airlines · UA 1209 Depart at 2:12pm from Portland (PDX) Fly for 4h 13m Arrive at 8:25pm in Chicago (ORD)

Layover in Chicago for 1h 4m

Tue Jul 15th 2025 United Airlines · UA 5280 Depart at 9:29pm from Chicago (ORD) Fly for 1h 31m Arrive at 11:00pm in Des Moines (DSM)
US$380

10:55am - 8:15pm
Sat Jul 19th 2025

7h 20m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sat Jul 19th 2025 United Airlines · UA 1027 Depart at 10:55am from Portland (PDX) Fly for 2h 35m Arrive at 2:30pm in Denver (DEN)

Layover in Denver for 3h 0m

Sat Jul 19th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$380

12:54pm - 10:17pm
Sat Jul 19th 2025

7h 23m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sat Jul 19th 2025 United Airlines · UA 1794 Depart at 12:54pm from Portland (PDX) Fly for 4h 16m Arrive at 7:10pm in Houston (IAH)

Layover in Houston for 0h 45m

Sat Jul 19th 2025 United Airlines · UA 1780 Depart at 7:55pm from Houston (IAH) Fly for 2h 22m Arrive at 10:17pm in Des Moines (DSM)
US$380

12:54pm - 10:17pm
Tue Jul 15th 2025

7h 23m
Portland (PDX) → Des Moines (DSM)

1 Stop

Tue Jul 15th 2025 United Airlines · UA 1794 Depart at 12:54pm from Portland (PDX) Fly for 4h 16m Arrive at 7:10pm in Houston (IAH)

Layover in Houston for 0h 45m

Tue Jul 15th 2025 United Airlines · UA 1780 Depart at 7:55pm from Houston (IAH) Fly for 2h 22m Arrive at 10:17pm in Des Moines (DSM)
US$380

10:48am - 9:47pm
Tue Jul 15th 2025

8h 59m
Portland (PDX) → Des Moines (DSM)

1 Stop

Tue Jul 15th 2025 United Airlines · UA 534 Depart at 10:48am from Portland (PDX) Fly for 4h 8m Arrive at 4:56pm in Chicago (ORD)

Layover in Chicago for 3h 24m

Tue Jul 15th 2025 United Airlines · UA 1531 Depart at 8:20pm from Chicago (ORD) Fly for 1h 27m Arrive at 9:47pm in Des Moines (DSM)
US$381

10:55am - 8:15pm
Tue Jul 15th 2025

7h 20m
Portland (PDX) → Des Moines (DSM)

1 Stop

Tue Jul 15th 2025 United Airlines · UA 1027 Depart at 10:55am from Portland (PDX) Fly for 2h 35m Arrive at 2:30pm in Denver (DEN)

Layover in Denver for 3h 0m

Tue Jul 15th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$383

2:12pm - 11:00pm
Wed Jul 16th 2025

6h 48m
Portland (PDX) → Des Moines (DSM)

1 Stop

Wed Jul 16th 2025 United Airlines · UA 1209 Depart at 2:12pm from Portland (PDX) Fly for 4h 13m Arrive at 8:25pm in Chicago (ORD)

Layover in Chicago for 1h 4m

Wed Jul 16th 2025 United Airlines · UA 5280 Depart at 9:29pm from Chicago (ORD) Fly for 1h 31m Arrive at 11:00pm in Des Moines (DSM)
US$386

1:37pm - 11:59pm
Tue Jul 15th 2025

8h 22m
Portland (PDX) → Des Moines (DSM)

2 Stops

Tue Jul 15th 2025 United Airlines · UA 776 Depart at 1:37pm from Portland (PDX) Fly for 1h 53m Arrive at 3:30pm in San Francisco (SFO)

Layover in San Francisco for 0h 52m

Tue Jul 15th 2025 United Airlines · UA 297 Depart at 4:22pm from San Francisco (SFO) Fly for 2h 43m Arrive at 8:05pm in Denver (DEN)

Layover in Denver for 0h 58m

Tue Jul 15th 2025 United Airlines · UA 5954 Depart at 9:03pm from Denver (DEN) Fly for 1h 56m Arrive at 11:59pm in Des Moines (DSM)
US$388

1:37pm - 11:59pm
Wed Jul 16th 2025

8h 22m
Portland (PDX) → Des Moines (DSM)

2 Stops

Wed Jul 16th 2025 United Airlines · UA 776 Depart at 1:37pm from Portland (PDX) Fly for 1h 53m Arrive at 3:30pm in San Francisco (SFO)

Layover in San Francisco for 0h 52m

Wed Jul 16th 2025 United Airlines · UA 297 Depart at 4:22pm from San Francisco (SFO) Fly for 2h 43m Arrive at 8:05pm in Denver (DEN)

Layover in Denver for 0h 58m

Wed Jul 16th 2025 United Airlines · UA 5954 Depart at 9:03pm from Denver (DEN) Fly for 1h 56m Arrive at 11:59pm in Des Moines (DSM)
US$388

9:47am - 8:15pm
Tue Jul 15th 2025

8h 28m
Portland (PDX) → Des Moines (DSM)

2 Stops

Tue Jul 15th 2025 United Airlines · UA 1998 Depart at 9:47am from Portland (PDX) Fly for 1h 53m Arrive at 11:40am in San Francisco (SFO)

Layover in San Francisco for 1h 15m

Tue Jul 15th 2025 United Airlines · UA 1333 Depart at 12:55pm from San Francisco (SFO) Fly for 2h 41m Arrive at 4:36pm in Denver (DEN)

Layover in Denver for 0h 54m

Tue Jul 15th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$427

10:52pm - 9:02am
Sun Jul 20th 2025

8h 10m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sun Jul 20th 2025 Alaska Airlines · AS 1057 Depart at 10:52pm from Portland (PDX) Fly for 3h 48m Arrive at 4:40am in Dallas (DFW)

Layover in Dallas for 2h 24m

Mon Jul 21st 2025 Alaska Airlines · AS 6073 Depart at 7:04am from Dallas (DFW) Fly for 1h 58m Arrive at 9:02am in Des Moines (DSM)
US$479

10:55am - 8:15pm
Thu Jul 17th 2025

7h 20m
Portland (PDX) → Des Moines (DSM)

1 Stop

Thu Jul 17th 2025 United Airlines · UA 1027 Depart at 10:55am from Portland (PDX) Fly for 2h 35m Arrive at 2:30pm in Denver (DEN)

Layover in Denver for 3h 0m

Thu Jul 17th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$479

12:54pm - 10:17pm
Thu Jul 17th 2025

7h 23m
Portland (PDX) → Des Moines (DSM)

1 Stop

Thu Jul 17th 2025 United Airlines · UA 1794 Depart at 12:54pm from Portland (PDX) Fly for 4h 16m Arrive at 7:10pm in Houston (IAH)

Layover in Houston for 0h 45m

Thu Jul 17th 2025 United Airlines · UA 1780 Depart at 7:55pm from Houston (IAH) Fly for 2h 22m Arrive at 10:17pm in Des Moines (DSM)
US$482

12:55pm - 8:15pm
Fri Jul 18th 2025

5h 20m
Portland (PDX) → Des Moines (DSM)

1 Stop

Fri Jul 18th 2025 United Airlines · UA 2254 Depart at 12:55pm from Portland (PDX) Fly for 2h 40m Arrive at 4:35pm in Denver (DEN)

Layover in Denver for 0h 55m

Fri Jul 18th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$482

8:50am - 4:15pm
Fri Jul 18th 2025

5h 25m
Portland (PDX) → Des Moines (DSM)

1 Stop

Fri Jul 18th 2025 United Airlines · UA 2375 Depart at 8:50am from Portland (PDX) Fly for 2h 35m Arrive at 12:25pm in Denver (DEN)

Layover in Denver for 1h 5m

Fri Jul 18th 2025 United Airlines · UA 2265 Depart at 1:30pm from Denver (DEN) Fly for 1h 45m Arrive at 4:15pm in Des Moines (DSM)
US$482

4:16pm - 11:59pm
Fri Jul 18th 2025

5h 43m
Portland (PDX) → Des Moines (DSM)

1 Stop

Fri Jul 18th 2025 United Airlines · UA 2190 Depart at 4:16pm from Portland (PDX) Fly for 2h 39m Arrive at 7:55pm in Denver (DEN)

Layover in Denver for 1h 8m

Fri Jul 18th 2025 United Airlines · UA 5954 Depart at 9:03pm from Denver (DEN) Fly for 1h 56m Arrive at 11:59pm in Des Moines (DSM)
US$482

5:00am - 12:49pm
Fri Jul 18th 2025

5h 49m
Portland (PDX) → Des Moines (DSM)

1 Stop

Fri Jul 18th 2025 United Airlines · UA 459 Depart at 5:00am from Portland (PDX) Fly for 2h 34m Arrive at 8:34am in Denver (DEN)

Layover in Denver for 1h 21m

Fri Jul 18th 2025 United Airlines · UA 5228 Depart at 9:55am from Denver (DEN) Fly for 1h 54m Arrive at 12:49pm in Des Moines (DSM)
US$483

12:55pm - 8:15pm
Tue Jul 15th 2025

5h 20m
Portland (PDX) → Des Moines (DSM)

1 Stop

Tue Jul 15th 2025 United Airlines · UA 2254 Depart at 12:55pm from Portland (PDX) Fly for 2h 40m Arrive at 4:35pm in Denver (DEN)

Layover in Denver for 0h 55m

Tue Jul 15th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$485

12:55pm - 8:15pm
Thu Jul 17th 2025

5h 20m
Portland (PDX) → Des Moines (DSM)

1 Stop

Thu Jul 17th 2025 United Airlines · UA 2254 Depart at 12:55pm from Portland (PDX) Fly for 2h 40m Arrive at 4:35pm in Denver (DEN)

Layover in Denver for 0h 55m

Thu Jul 17th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$485

8:50am - 4:15pm
Thu Jul 17th 2025

5h 25m
Portland (PDX) → Des Moines (DSM)

1 Stop

Thu Jul 17th 2025 United Airlines · UA 2375 Depart at 8:50am from Portland (PDX) Fly for 2h 35m Arrive at 12:25pm in Denver (DEN)

Layover in Denver for 1h 5m

Thu Jul 17th 2025 United Airlines · UA 2265 Depart at 1:30pm from Denver (DEN) Fly for 1h 45m Arrive at 4:15pm in Des Moines (DSM)
US$485

4:16pm - 11:59pm
Thu Jul 17th 2025

5h 43m
Portland (PDX) → Des Moines (DSM)

1 Stop

Thu Jul 17th 2025 United Airlines · UA 2190 Depart at 4:16pm from Portland (PDX) Fly for 2h 39m Arrive at 7:55pm in Denver (DEN)

Layover in Denver for 1h 8m

Thu Jul 17th 2025 United Airlines · UA 5954 Depart at 9:03pm from Denver (DEN) Fly for 1h 56m Arrive at 11:59pm in Des Moines (DSM)
US$485

5:00am - 12:49pm
Thu Jul 17th 2025

5h 49m
Portland (PDX) → Des Moines (DSM)

1 Stop

Thu Jul 17th 2025 United Airlines · UA 459 Depart at 5:00am from Portland (PDX) Fly for 2h 34m Arrive at 8:34am in Denver (DEN)

Layover in Denver for 1h 21m

Thu Jul 17th 2025 United Airlines · UA 5228 Depart at 9:55am from Denver (DEN) Fly for 1h 54m Arrive at 12:49pm in Des Moines (DSM)
US$486

12:55pm - 8:15pm
Sat Jul 19th 2025

5h 20m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sat Jul 19th 2025 United Airlines · UA 2254 Depart at 12:55pm from Portland (PDX) Fly for 2h 40m Arrive at 4:35pm in Denver (DEN)

Layover in Denver for 0h 55m

Sat Jul 19th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$486

8:50am - 4:20pm
Sat Jul 19th 2025

5h 30m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sat Jul 19th 2025 United Airlines · UA 2375 Depart at 8:50am from Portland (PDX) Fly for 2h 35m Arrive at 12:25pm in Denver (DEN)

Layover in Denver for 1h 5m

Sat Jul 19th 2025 United Airlines · UA 5406 Depart at 1:30pm from Denver (DEN) Fly for 1h 50m Arrive at 4:20pm in Des Moines (DSM)
US$486

5:00am - 12:49pm
Sat Jul 19th 2025

5h 49m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sat Jul 19th 2025 United Airlines · UA 459 Depart at 5:00am from Portland (PDX) Fly for 2h 34m Arrive at 8:34am in Denver (DEN)

Layover in Denver for 1h 21m

Sat Jul 19th 2025 United Airlines · UA 5228 Depart at 9:55am from Denver (DEN) Fly for 1h 54m Arrive at 12:49pm in Des Moines (DSM)
US$536

10:52pm - 9:02am
Fri Jul 18th 2025

8h 10m
Portland (PDX) → Des Moines (DSM)

1 Stop

Fri Jul 18th 2025 Alaska Airlines · AS 1057 Depart at 10:52pm from Portland (PDX) Fly for 3h 48m Arrive at 4:40am in Dallas (DFW)

Layover in Dallas for 2h 24m

Sat Jul 19th 2025 Alaska Airlines · AS 6073 Depart at 7:04am from Dallas (DFW) Fly for 1h 58m Arrive at 9:02am in Des Moines (DSM)
US$536

10:52pm - 9:02am
Thu Jul 17th 2025

8h 10m
Portland (PDX) → Des Moines (DSM)

1 Stop

Thu Jul 17th 2025 Alaska Airlines · AS 1057 Depart at 10:52pm from Portland (PDX) Fly for 3h 48m Arrive at 4:40am in Dallas (DFW)

Layover in Dallas for 2h 24m

Fri Jul 18th 2025 Alaska Airlines · AS 6073 Depart at 7:04am from Dallas (DFW) Fly for 1h 58m Arrive at 9:02am in Des Moines (DSM)
US$536

10:52pm - 9:02am
Mon Jul 14th 2025

8h 10m
Portland (PDX) → Des Moines (DSM)

1 Stop

Mon Jul 14th 2025 Alaska Airlines · AS 1057 Depart at 10:52pm from Portland (PDX) Fly for 3h 48m Arrive at 4:40am in Dallas (DFW)

Layover in Dallas for 2h 24m

Tue Jul 15th 2025 Alaska Airlines · AS 6073 Depart at 7:04am from Dallas (DFW) Fly for 1h 58m Arrive at 9:02am in Des Moines (DSM)
US$651

7:02am - 5:39pm
Sun Jul 20th 2025

8h 37m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sun Jul 20th 2025 Alaska Airlines · AS 324 Depart at 7:02am from Portland (PDX) Fly for 4h 5m Arrive at 1:07pm in Chicago (ORD)

Layover in Chicago for 3h 8m

Sun Jul 20th 2025 Alaska Airlines · AS 6282 Depart at 4:15pm from Chicago (ORD) Fly for 1h 24m Arrive at 5:39pm in Des Moines (DSM)
US$744

7:00am - 4:15pm
Sun Jul 20th 2025

7h 15m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sun Jul 20th 2025 Hawaiian Airlines · HA 6337 Depart at 7:00am from Portland (PDX) Fly for 2h 37m Arrive at 10:37am in Denver (DEN)

Layover in Denver for 2h 53m

Sun Jul 20th 2025 United Airlines · UA 2265 Depart at 1:30pm from Denver (DEN) Fly for 1h 45m Arrive at 4:15pm in Des Moines (DSM)
US$751

8:50am - 8:15pm
Sun Jul 20th 2025

9h 25m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sun Jul 20th 2025 United Airlines · UA 2375 Depart at 8:50am from Portland (PDX) Fly for 2h 35m Arrive at 12:25pm in Denver (DEN)

Layover in Denver for 5h 5m

Sun Jul 20th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$769

12:54pm - 10:17pm
Sun Jul 20th 2025

7h 23m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sun Jul 20th 2025 United Airlines · UA 1794 Depart at 12:54pm from Portland (PDX) Fly for 4h 16m Arrive at 7:10pm in Houston (IAH)

Layover in Houston for 0h 45m

Sun Jul 20th 2025 United Airlines · UA 1780 Depart at 7:55pm from Houston (IAH) Fly for 2h 22m Arrive at 10:17pm in Des Moines (DSM)
US$770

5:00am - 12:49pm
Sun Jul 20th 2025

5h 49m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sun Jul 20th 2025 United Airlines · UA 459 Depart at 5:00am from Portland (PDX) Fly for 2h 34m Arrive at 8:34am in Denver (DEN)

Layover in Denver for 1h 21m

Sun Jul 20th 2025 United Airlines · UA 5228 Depart at 9:55am from Denver (DEN) Fly for 1h 54m Arrive at 12:49pm in Des Moines (DSM)
US$877

12:55pm - 8:15pm
Sun Jul 20th 2025

5h 20m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sun Jul 20th 2025 United Airlines · UA 2254 Depart at 12:55pm from Portland (PDX) Fly for 2h 40m Arrive at 4:35pm in Denver (DEN)

Layover in Denver for 0h 55m

Sun Jul 20th 2025 United Airlines · UA 2238 Depart at 5:30pm from Denver (DEN) Fly for 1h 45m Arrive at 8:15pm in Des Moines (DSM)
US$991

8:50am - 4:15pm
Sun Jul 20th 2025

5h 25m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sun Jul 20th 2025 United Airlines · UA 2375 Depart at 8:50am from Portland (PDX) Fly for 2h 35m Arrive at 12:25pm in Denver (DEN)

Layover in Denver for 1h 5m

Sun Jul 20th 2025 United Airlines · UA 2265 Depart at 1:30pm from Denver (DEN) Fly for 1h 45m Arrive at 4:15pm in Des Moines (DSM)
US$996

2:12pm - 11:00pm
Sun Jul 20th 2025

6h 48m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sun Jul 20th 2025 United Airlines · UA 1209 Depart at 2:12pm from Portland (PDX) Fly for 4h 13m Arrive at 8:25pm in Chicago (ORD)

Layover in Chicago for 1h 4m

Sun Jul 20th 2025 United Airlines · UA 5280 Depart at 9:29pm from Chicago (ORD) Fly for 1h 31m Arrive at 11:00pm in Des Moines (DSM)
US$1462

7:02am - 5:33pm
Sat Jul 19th 2025

8h 31m
Portland (PDX) → Des Moines (DSM)

1 Stop

Sat Jul 19th 2025 Alaska Airlines · AS 324 Depart at 7:02am from Portland (PDX) Fly for 4h 5m Arrive at 1:07pm in Chicago (ORD)

Layover in Chicago for 3h 1m

Sat Jul 19th 2025 Alaska Airlines · AS 6282 Depart at 4:08pm from Chicago (ORD) Fly for 1h 25m Arrive at 5:33pm in Des Moines (DSM)

Sarah Belizaire

@sarahbb1

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John Ford

@eyupitsjohn

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Roaming Sonaa

@roamingsonaa

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Andy Travels

@andy_travels

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Travel With Bender

@travelwitbender

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Wesley Mergard

@travel.with.wes

One useful tool I've found for evaluating different departure and return dates is called FlightList.io. You can quickly scan different travel date ranges, carriers and one way flight options to easily determine the cheapest flight combinations for your trip.

Flights from Portland to Des Moines (PDX to DSM)

Sarah Belizaire

John Ford

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Andy Travels

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