Flights from Panama City to Italy (PTY to IT)

Discover more affordable routes and cheaper dates from Panama City to Italy (PTY to IT) within a date range.

⭐ Search by country or region to discover more affordable routes, like Netherlands → Italy or Europe → South East Asia.

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US$1226.55

8:25pm - 8:55pm
Fri Jun 20th 2025

17h 30m
Panama (PTY) → Milan (MXP)

1 Stop

6:50am - 5:45pm
Mon Jun 30th 2025

17h 55m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 5h 30m

Sat Jun 21st 2025 Ryanair · FR 3009 Depart at 6:45pm from Madrid (MAD) Fly for 2h 10m Arrive at 8:55pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1131 Depart at 6:50am from Milan (MXP) Fly for 1h 35m Arrive at 8:25am in Paris (CDG)

Layover in Paris for 5h 30m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1247

8:25pm - 5:15pm
Fri Jun 20th 2025

13h 50m
Panama (PTY) → Milan (MXP)

1 Stop

6:50am - 5:45pm
Mon Jun 30th 2025

17h 55m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 1h 55m

Sat Jun 21st 2025 Air Europa · UX 1061 Depart at 3:10pm from Madrid (MAD) Fly for 2h 5m Arrive at 5:15pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1131 Depart at 6:50am from Milan (MXP) Fly for 1h 35m Arrive at 8:25am in Paris (CDG)

Layover in Paris for 5h 30m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1247

9:55pm - 11:45pm
Fri Jun 20th 2025

18h 50m
Panama (PTY) → Milan (MXP)

1 Stop

6:50am - 5:45pm
Mon Jun 30th 2025

17h 55m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1877 Depart at 9:50pm from Istanbul (IST) Fly for 2h 55m Arrive at 11:45pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1131 Depart at 6:50am from Milan (MXP) Fly for 1h 35m Arrive at 8:25am in Paris (CDG)

Layover in Paris for 5h 30m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1260.51

8:25pm - 9:00pm
Fri Jun 20th 2025

17h 35m
Panama (PTY) → Milan (BGY)

2 Stops

6:50am - 5:45pm
Mon Jun 30th 2025

17h 55m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 1h 40m

Sat Jun 21st 2025 Air Europa · UX 1155 Depart at 2:55pm from Madrid (MAD) Fly for 1h 20m Arrive at 3:15pm in Lisbon (LIS)

Layover in Lisbon for 2h 0m

Sat Jun 21st 2025 Ryanair · FR 2086 Depart at 5:15pm from Lisbon (LIS) Fly for 2h 45m Arrive at 9:00pm in Milan (BGY)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1131 Depart at 6:50am from Milan (MXP) Fly for 1h 35m Arrive at 8:25am in Paris (CDG)

Layover in Paris for 5h 30m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1276.61

11:05am - 3:10pm
Fri Jun 20th 2025

21h 5m
Panama (PTY) → Milan (MXP)

2 Stops

6:50am - 5:45pm
Mon Jun 30th 2025

17h 55m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Avianca · AV 8383 Depart at 11:05am from Panama (PTY) Fly for 1h 30m Arrive at 12:35pm in Bogotá (BOG)

Layover in Bogotá for 2h 35m

Fri Jun 20th 2025 Avianca · AV 26 Depart at 3:10pm from Bogotá (BOG) Fly for 9h 30m Arrive at 7:40am in Madrid (MAD)

Layover in Madrid for 5h 20m

Sat Jun 21st 2025 Ryanair · FR 2753 Depart at 1:00pm from Madrid (MAD) Fly for 2h 10m Arrive at 3:10pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1131 Depart at 6:50am from Milan (MXP) Fly for 1h 35m Arrive at 8:25am in Paris (CDG)

Layover in Paris for 5h 30m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1287.66

9:55pm - 11:30pm
Fri Jun 20th 2025

18h 35m
Panama (PTY) → Rome (FCO)

1 Stop

5:45am - 3:40pm
Mon Jun 30th 2025

16h 55m
Rome (FCO) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1361 Depart at 9:50pm from Istanbul (IST) Fly for 2h 40m Arrive at 11:30pm in Rome (FCO)

Stay in Rome for 8 nights

Mon Jun 30th 2025 Ryanair · FR 9601 Depart at 5:45am from Rome (FCO) Fly for 2h 40m Arrive at 8:25am in Madrid (MAD)

Layover in Madrid for 3h 35m

Mon Jun 30th 2025 Iberia Airlines · IB 257 Depart at 12:00pm from Madrid (MAD) Fly for 10h 40m Arrive at 3:40pm in Panama (PTY)
US$1294.91

8:25pm - 8:55pm
Fri Jun 20th 2025

17h 30m
Panama (PTY) → Milan (MXP)

1 Stop

6:00am - 3:40pm
Mon Jun 30th 2025

16h 40m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 5h 30m

Sat Jun 21st 2025 Ryanair · FR 3009 Depart at 6:45pm from Madrid (MAD) Fly for 2h 10m Arrive at 8:55pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Wizz Air Malta · W4 6311 Depart at 6:00am from Milan (MXP) Fly for 2h 30m Arrive at 8:30am in Madrid (MAD)

Layover in Madrid for 3h 30m

Mon Jun 30th 2025 Iberia Airlines · IB 257 Depart at 12:00pm from Madrid (MAD) Fly for 10h 40m Arrive at 3:40pm in Panama (PTY)
US$1311

9:55pm - 11:30pm
Fri Jun 20th 2025

18h 35m
Panama (PTY) → Rome (FCO)

1 Stop

6:05am - 5:45pm
Mon Jun 30th 2025

18h 40m
Rome (FCO) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1361 Depart at 9:50pm from Istanbul (IST) Fly for 2h 40m Arrive at 11:30pm in Rome (FCO)

Stay in Rome for 8 nights

Mon Jun 30th 2025 Air France · AF 1005 Depart at 6:05am from Rome (FCO) Fly for 2h 15m Arrive at 8:20am in Paris (CDG)

Layover in Paris for 5h 35m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1328.87

8:25pm - 9:00pm
Fri Jun 20th 2025

17h 35m
Panama (PTY) → Milan (BGY)

2 Stops

6:00am - 3:40pm
Mon Jun 30th 2025

16h 40m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 1h 40m

Sat Jun 21st 2025 Air Europa · UX 1155 Depart at 2:55pm from Madrid (MAD) Fly for 1h 20m Arrive at 3:15pm in Lisbon (LIS)

Layover in Lisbon for 2h 0m

Sat Jun 21st 2025 Ryanair · FR 2086 Depart at 5:15pm from Lisbon (LIS) Fly for 2h 45m Arrive at 9:00pm in Milan (BGY)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Wizz Air Malta · W4 6311 Depart at 6:00am from Milan (MXP) Fly for 2h 30m Arrive at 8:30am in Madrid (MAD)

Layover in Madrid for 3h 30m

Mon Jun 30th 2025 Iberia Airlines · IB 257 Depart at 12:00pm from Madrid (MAD) Fly for 10h 40m Arrive at 3:40pm in Panama (PTY)
US$1336

8:25pm - 5:15pm
Fri Jun 20th 2025

13h 50m
Panama (PTY) → Milan (MXP)

1 Stop

11:25am - 5:45pm
Mon Jun 30th 2025

13h 20m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 1h 55m

Sat Jun 21st 2025 Air Europa · UX 1061 Depart at 3:10pm from Madrid (MAD) Fly for 2h 5m Arrive at 5:15pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1331 Depart at 11:25am from Milan (MXP) Fly for 1h 30m Arrive at 12:55pm in Paris (CDG)

Layover in Paris for 1h 0m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1336

9:55pm - 11:45pm
Fri Jun 20th 2025

18h 50m
Panama (PTY) → Milan (MXP)

1 Stop

11:25am - 5:45pm
Mon Jun 30th 2025

13h 20m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1877 Depart at 9:50pm from Istanbul (IST) Fly for 2h 55m Arrive at 11:45pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1331 Depart at 11:25am from Milan (MXP) Fly for 1h 30m Arrive at 12:55pm in Paris (CDG)

Layover in Paris for 1h 0m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1339.19

8:25pm - 8:50pm
Fri Jun 20th 2025

17h 25m
Panama (PTY) → Rome (FCO)

1 Stop

7:05pm - 10:25am
Mon Jun 30th 2025

22h 20m
Rome (FCO) → Panama (PTY)

2 Stops

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 5h 10m

Sat Jun 21st 2025 Ryanair · FR 2436 Depart at 6:25pm from Madrid (MAD) Fly for 2h 25m Arrive at 8:50pm in Rome (FCO)

Stay in Rome for 8 nights

Mon Jun 30th 2025 Norse Atlantic Airways · N0 401 Depart at 7:05pm from Rome (FCO) Fly for 9h 25m Arrive at 10:30pm in New York (JFK)

Layover in New York for 5h 5m

Tue Jul 1st 2025 Avianca · AV 571 Depart at 3:35am from New York (JFK) Fly for 4h 55m Arrive at 6:30am in San Salvador (SAL)

Layover in San Salvador for 1h 0m

Tue Jul 1st 2025 Avianca · AV 323 Depart at 7:30am from San Salvador (SAL) Fly for 1h 55m Arrive at 10:25am in Panama (PTY)
US$1343.95

9:55pm - 11:45pm
Fri Jun 20th 2025

18h 50m
Panama (PTY) → Milan (MXP)

1 Stop

9:55am - 6:40pm
Mon Jun 30th 2025

15h 45m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1877 Depart at 9:50pm from Istanbul (IST) Fly for 2h 55m Arrive at 11:45pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Ryanair · FR 2752 Depart at 9:55am from Milan (MXP) Fly for 2h 25m Arrive at 12:20pm in Madrid (MAD)

Layover in Madrid for 2h 45m

Mon Jun 30th 2025 Air Europa · UX 55 Depart at 3:05pm from Madrid (MAD) Fly for 10h 35m Arrive at 6:40pm in Panama (PTY)
US$1344

8:25pm - 5:15pm
Fri Jun 20th 2025

13h 50m
Panama (PTY) → Milan (MXP)

1 Stop

9:55am - 6:40pm
Mon Jun 30th 2025

15h 45m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 1h 55m

Sat Jun 21st 2025 Air Europa · UX 1061 Depart at 3:10pm from Madrid (MAD) Fly for 2h 5m Arrive at 5:15pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Ryanair · FR 2752 Depart at 9:55am from Milan (MXP) Fly for 2h 25m Arrive at 12:20pm in Madrid (MAD)

Layover in Madrid for 2h 45m

Mon Jun 30th 2025 Air Europa · UX 55 Depart at 3:05pm from Madrid (MAD) Fly for 10h 35m Arrive at 6:40pm in Panama (PTY)
US$1344.97

11:05am - 3:10pm
Fri Jun 20th 2025

21h 5m
Panama (PTY) → Milan (MXP)

2 Stops

6:00am - 3:40pm
Mon Jun 30th 2025

16h 40m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Avianca · AV 8383 Depart at 11:05am from Panama (PTY) Fly for 1h 30m Arrive at 12:35pm in Bogotá (BOG)

Layover in Bogotá for 2h 35m

Fri Jun 20th 2025 Avianca · AV 26 Depart at 3:10pm from Bogotá (BOG) Fly for 9h 30m Arrive at 7:40am in Madrid (MAD)

Layover in Madrid for 5h 20m

Sat Jun 21st 2025 Ryanair · FR 2753 Depart at 1:00pm from Madrid (MAD) Fly for 2h 10m Arrive at 3:10pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Wizz Air Malta · W4 6311 Depart at 6:00am from Milan (MXP) Fly for 2h 30m Arrive at 8:30am in Madrid (MAD)

Layover in Madrid for 3h 30m

Mon Jun 30th 2025 Iberia Airlines · IB 257 Depart at 12:00pm from Madrid (MAD) Fly for 10h 40m Arrive at 3:40pm in Panama (PTY)
US$1345

9:55pm - 11:30pm
Fri Jun 20th 2025

18h 35m
Panama (PTY) → Rome (FCO)

1 Stop

7:05pm - 10:25am
Mon Jun 30th 2025

22h 20m
Rome (FCO) → Panama (PTY)

2 Stops

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1361 Depart at 9:50pm from Istanbul (IST) Fly for 2h 40m Arrive at 11:30pm in Rome (FCO)

Stay in Rome for 8 nights

Mon Jun 30th 2025 Norse Atlantic Airways · N0 401 Depart at 7:05pm from Rome (FCO) Fly for 9h 25m Arrive at 10:30pm in New York (JFK)

Layover in New York for 5h 5m

Tue Jul 1st 2025 Avianca · AV 571 Depart at 3:35am from New York (JFK) Fly for 4h 55m Arrive at 6:30am in San Salvador (SAL)

Layover in San Salvador for 1h 0m

Tue Jul 1st 2025 Avianca · AV 323 Depart at 7:30am from San Salvador (SAL) Fly for 1h 55m Arrive at 10:25am in Panama (PTY)
US$1353

8:25pm - 5:15pm
Fri Jun 20th 2025

13h 50m
Panama (PTY) → Milan (MXP)

1 Stop

6:00am - 3:40pm
Mon Jun 30th 2025

16h 40m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 1h 55m

Sat Jun 21st 2025 Air Europa · UX 1061 Depart at 3:10pm from Madrid (MAD) Fly for 2h 5m Arrive at 5:15pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Wizz Air Malta · W4 6311 Depart at 6:00am from Milan (MXP) Fly for 2h 30m Arrive at 8:30am in Madrid (MAD)

Layover in Madrid for 3h 30m

Mon Jun 30th 2025 Iberia Airlines · IB 257 Depart at 12:00pm from Madrid (MAD) Fly for 10h 40m Arrive at 3:40pm in Panama (PTY)
US$1353

9:55pm - 11:45pm
Fri Jun 20th 2025

18h 50m
Panama (PTY) → Milan (MXP)

1 Stop

6:00am - 3:40pm
Mon Jun 30th 2025

16h 40m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1877 Depart at 9:50pm from Istanbul (IST) Fly for 2h 55m Arrive at 11:45pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Wizz Air Malta · W4 6311 Depart at 6:00am from Milan (MXP) Fly for 2h 30m Arrive at 8:30am in Madrid (MAD)

Layover in Madrid for 3h 30m

Mon Jun 30th 2025 Iberia Airlines · IB 257 Depart at 12:00pm from Madrid (MAD) Fly for 10h 40m Arrive at 3:40pm in Panama (PTY)
US$1375

8:25pm - 5:15pm
Fri Jun 20th 2025

13h 50m
Panama (PTY) → Milan (MXP)

1 Stop

6:30am - 5:45pm
Mon Jun 30th 2025

18h 15m
Milan (LIN) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 1h 55m

Sat Jun 21st 2025 Air Europa · UX 1061 Depart at 3:10pm from Madrid (MAD) Fly for 2h 5m Arrive at 5:15pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1733 Depart at 6:30am from Milan (LIN) Fly for 1h 35m Arrive at 8:05am in Paris (CDG)

Layover in Paris for 5h 50m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1395.77

8:25pm - 8:50pm
Fri Jun 20th 2025

17h 25m
Panama (PTY) → Rome (FCO)

1 Stop

6:05am - 3:40pm
Mon Jun 30th 2025

16h 35m
Rome (FCO) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 5h 10m

Sat Jun 21st 2025 Ryanair · FR 2436 Depart at 6:25pm from Madrid (MAD) Fly for 2h 25m Arrive at 8:50pm in Rome (FCO)

Stay in Rome for 8 nights

Mon Jun 30th 2025 Wizz Air Malta · W4 6011 Depart at 6:05am from Rome (FCO) Fly for 2h 40m Arrive at 8:45am in Madrid (MAD)

Layover in Madrid for 3h 15m

Mon Jun 30th 2025 Iberia Airlines · IB 257 Depart at 12:00pm from Madrid (MAD) Fly for 10h 40m Arrive at 3:40pm in Panama (PTY)
US$1396.65

8:25pm - 8:55pm
Fri Jun 20th 2025

17h 30m
Panama (PTY) → Milan (MXP)

1 Stop

9:55am - 6:40pm
Mon Jun 30th 2025

15h 45m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 5h 30m

Sat Jun 21st 2025 Ryanair · FR 3009 Depart at 6:45pm from Madrid (MAD) Fly for 2h 10m Arrive at 8:55pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Ryanair · FR 2752 Depart at 9:55am from Milan (MXP) Fly for 2h 25m Arrive at 12:20pm in Madrid (MAD)

Layover in Madrid for 2h 45m

Mon Jun 30th 2025 Air Europa · UX 55 Depart at 3:05pm from Madrid (MAD) Fly for 10h 35m Arrive at 6:40pm in Panama (PTY)
US$1408

9:55pm - 11:30pm
Fri Jun 20th 2025

18h 35m
Panama (PTY) → Rome (FCO)

1 Stop

6:05am - 3:40pm
Mon Jun 30th 2025

16h 35m
Rome (FCO) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1361 Depart at 9:50pm from Istanbul (IST) Fly for 2h 40m Arrive at 11:30pm in Rome (FCO)

Stay in Rome for 8 nights

Mon Jun 30th 2025 Wizz Air Malta · W4 6011 Depart at 6:05am from Rome (FCO) Fly for 2h 40m Arrive at 8:45am in Madrid (MAD)

Layover in Madrid for 3h 15m

Mon Jun 30th 2025 Iberia Airlines · IB 257 Depart at 12:00pm from Madrid (MAD) Fly for 10h 40m Arrive at 3:40pm in Panama (PTY)
US$1413

10:25am - 11:55am
Fri Jun 20th 2025

18h 30m
Panama (PTY) → Milan (MXP)

2 Stops

6:50am - 5:45pm
Mon Jun 30th 2025

17h 55m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Copa Airlines · CM 334 Depart at 10:25am from Panama (PTY) Fly for 3h 11m Arrive at 2:36pm in Miami (MIA)

Layover in Miami for 2h 39m

Fri Jun 20th 2025 Norse Atlantic UK · Z0 724 Depart at 5:15pm from Miami (MIA) Fly for 8h 40m Arrive at 6:55am in London (LGW)

Layover in London for 2h 0m

Sat Jun 21st 2025 Wizz Air Malta · W4 6302 Depart at 8:55am from London (LGW) Fly for 2h 0m Arrive at 11:55am in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1131 Depart at 6:50am from Milan (MXP) Fly for 1h 35m Arrive at 8:25am in Paris (CDG)

Layover in Paris for 5h 30m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1449.94

8:25pm - 8:50pm
Fri Jun 20th 2025

17h 25m
Panama (PTY) → Rome (FCO)

1 Stop

2:15pm - 8:55am
Mon Jun 30th 2025

25h 40m
Rome (FCO) → Panama (PTY)

2 Stops

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 5h 10m

Sat Jun 21st 2025 Ryanair · FR 2436 Depart at 6:25pm from Madrid (MAD) Fly for 2h 25m Arrive at 8:50pm in Rome (FCO)

Stay in Rome for 8 nights

Mon Jun 30th 2025 Air Transat · TS 309 Depart at 2:15pm from Rome (FCO) Fly for 9h 45m Arrive at 6:00pm in Toronto (YYZ)

Layover in Toronto for 5h 50m

Mon Jun 30th 2025 Avianca · AV 205 Depart at 11:50pm from Toronto (YYZ) Fly for 6h 5m Arrive at 4:55am in Bogotá (BOG)

Layover in Bogotá for 2h 15m

Tue Jul 1st 2025 Avianca · AV 58 Depart at 7:10am from Bogotá (BOG) Fly for 1h 45m Arrive at 8:55am in Panama (PTY)
US$1450.28

11:05am - 3:10pm
Fri Jun 20th 2025

21h 5m
Panama (PTY) → Milan (MXP)

2 Stops

9:55am - 6:40pm
Mon Jun 30th 2025

15h 45m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Avianca · AV 8383 Depart at 11:05am from Panama (PTY) Fly for 1h 30m Arrive at 12:35pm in Bogotá (BOG)

Layover in Bogotá for 2h 35m

Fri Jun 20th 2025 Avianca · AV 26 Depart at 3:10pm from Bogotá (BOG) Fly for 9h 30m Arrive at 7:40am in Madrid (MAD)

Layover in Madrid for 5h 20m

Sat Jun 21st 2025 Ryanair · FR 2753 Depart at 1:00pm from Madrid (MAD) Fly for 2h 10m Arrive at 3:10pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Ryanair · FR 2752 Depart at 9:55am from Milan (MXP) Fly for 2h 25m Arrive at 12:20pm in Madrid (MAD)

Layover in Madrid for 2h 45m

Mon Jun 30th 2025 Air Europa · UX 55 Depart at 3:05pm from Madrid (MAD) Fly for 10h 35m Arrive at 6:40pm in Panama (PTY)
US$1466.71

8:25pm - 5:15pm
Fri Jun 20th 2025

13h 50m
Panama (PTY) → Milan (MXP)

1 Stop

11:15pm - 4:50pm
Mon Jun 30th 2025

24h 35m
Milan (BGY) → Panama (PTY)

2 Stops

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 1h 55m

Sat Jun 21st 2025 Air Europa · UX 1061 Depart at 3:10pm from Madrid (MAD) Fly for 2h 5m Arrive at 5:15pm in Milan (MXP)

Stay in Milan for 9 nights

Mon Jun 30th 2025 Ryanair · FR 847 Depart at 11:15pm from Milan (BGY) Fly for 1h 40m Arrive at 12:55am in Barcelona (BCN)

Layover in Barcelona for 5h 25m

Tue Jul 1st 2025 KLM Royal Dutch Airlines · KL 1510 Depart at 6:20am from Barcelona (BCN) Fly for 2h 20m Arrive at 8:40am in Amsterdam (AMS)

Layover in Amsterdam for 4h 15m

Tue Jul 1st 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)
US$1466.90

10:25am - 11:55am
Fri Jun 20th 2025

18h 30m
Panama (PTY) → Milan (MXP)

2 Stops

9:55am - 6:40pm
Mon Jun 30th 2025

15h 45m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Copa Airlines · CM 334 Depart at 10:25am from Panama (PTY) Fly for 3h 11m Arrive at 2:36pm in Miami (MIA)

Layover in Miami for 2h 39m

Fri Jun 20th 2025 Norse Atlantic UK · Z0 724 Depart at 5:15pm from Miami (MIA) Fly for 8h 40m Arrive at 6:55am in London (LGW)

Layover in London for 2h 0m

Sat Jun 21st 2025 Wizz Air Malta · W4 6302 Depart at 8:55am from London (LGW) Fly for 2h 0m Arrive at 11:55am in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Ryanair · FR 2752 Depart at 9:55am from Milan (MXP) Fly for 2h 25m Arrive at 12:20pm in Madrid (MAD)

Layover in Madrid for 2h 45m

Mon Jun 30th 2025 Air Europa · UX 55 Depart at 3:05pm from Madrid (MAD) Fly for 10h 35m Arrive at 6:40pm in Panama (PTY)
US$1467

10:25am - 11:55am
Fri Jun 20th 2025

18h 30m
Panama (PTY) → Milan (MXP)

2 Stops

6:00am - 3:40pm
Mon Jun 30th 2025

16h 40m
Milan (MXP) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Copa Airlines · CM 334 Depart at 10:25am from Panama (PTY) Fly for 3h 11m Arrive at 2:36pm in Miami (MIA)

Layover in Miami for 2h 39m

Fri Jun 20th 2025 Norse Atlantic UK · Z0 724 Depart at 5:15pm from Miami (MIA) Fly for 8h 40m Arrive at 6:55am in London (LGW)

Layover in London for 2h 0m

Sat Jun 21st 2025 Wizz Air Malta · W4 6302 Depart at 8:55am from London (LGW) Fly for 2h 0m Arrive at 11:55am in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Wizz Air Malta · W4 6311 Depart at 6:00am from Milan (MXP) Fly for 2h 30m Arrive at 8:30am in Madrid (MAD)

Layover in Madrid for 3h 30m

Mon Jun 30th 2025 Iberia Airlines · IB 257 Depart at 12:00pm from Madrid (MAD) Fly for 10h 40m Arrive at 3:40pm in Panama (PTY)
US$1468

10:25am - 12:55pm
Fri Jun 20th 2025

19h 30m
Panama (PTY) → Rome (FCO)

2 Stops

7:05pm - 10:25am
Mon Jun 30th 2025

22h 20m
Rome (FCO) → Panama (PTY)

2 Stops

Fri Jun 20th 2025 Copa Airlines · CM 334 Depart at 10:25am from Panama (PTY) Fly for 3h 11m Arrive at 2:36pm in Miami (MIA)

Layover in Miami for 2h 39m

Fri Jun 20th 2025 Norse Atlantic UK · Z0 724 Depart at 5:15pm from Miami (MIA) Fly for 8h 40m Arrive at 6:55am in London (LGW)

Layover in London for 2h 25m

Sat Jun 21st 2025 Wizz Air Malta · W4 6002 Depart at 9:20am from London (LGW) Fly for 2h 35m Arrive at 12:55pm in Rome (FCO)

Stay in Rome for 9 nights

Mon Jun 30th 2025 Norse Atlantic Airways · N0 401 Depart at 7:05pm from Rome (FCO) Fly for 9h 25m Arrive at 10:30pm in New York (JFK)

Layover in New York for 5h 5m

Tue Jul 1st 2025 Avianca · AV 571 Depart at 3:35am from New York (JFK) Fly for 4h 55m Arrive at 6:30am in San Salvador (SAL)

Layover in San Salvador for 1h 0m

Tue Jul 1st 2025 Avianca · AV 323 Depart at 7:30am from San Salvador (SAL) Fly for 1h 55m Arrive at 10:25am in Panama (PTY)
US$1468

9:55pm - 11:30pm
Fri Jun 20th 2025

18h 35m
Panama (PTY) → Rome (FCO)

1 Stop

2:15pm - 8:55am
Mon Jun 30th 2025

25h 40m
Rome (FCO) → Panama (PTY)

2 Stops

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1361 Depart at 9:50pm from Istanbul (IST) Fly for 2h 40m Arrive at 11:30pm in Rome (FCO)

Stay in Rome for 8 nights

Mon Jun 30th 2025 Air Transat · TS 309 Depart at 2:15pm from Rome (FCO) Fly for 9h 45m Arrive at 6:00pm in Toronto (YYZ)

Layover in Toronto for 5h 50m

Mon Jun 30th 2025 Avianca · AV 205 Depart at 11:50pm from Toronto (YYZ) Fly for 6h 5m Arrive at 4:55am in Bogotá (BOG)

Layover in Bogotá for 2h 15m

Tue Jul 1st 2025 Avianca · AV 58 Depart at 7:10am from Bogotá (BOG) Fly for 1h 45m Arrive at 8:55am in Panama (PTY)
US$1480

9:55pm - 11:30pm
Fri Jun 20th 2025

18h 35m
Panama (PTY) → Rome (FCO)

1 Stop

10:00am - 5:45pm
Mon Jun 30th 2025

14h 45m
Rome (FCO) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1361 Depart at 9:50pm from Istanbul (IST) Fly for 2h 40m Arrive at 11:30pm in Rome (FCO)

Stay in Rome for 8 nights

Mon Jun 30th 2025 Air France · AF 1205 Depart at 10:00am from Rome (FCO) Fly for 2h 10m Arrive at 12:10pm in Paris (CDG)

Layover in Paris for 1h 45m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)
US$1486

8:25pm - 5:15pm
Fri Jun 20th 2025

13h 50m
Panama (PTY) → Milan (MXP)

1 Stop

6:50am - 4:50pm
Mon Jun 30th 2025

17h 0m
Milan (MXP) → Panama (PTY)

2 Stops

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 1h 55m

Sat Jun 21st 2025 Air Europa · UX 1061 Depart at 3:10pm from Madrid (MAD) Fly for 2h 5m Arrive at 5:15pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1131 Depart at 6:50am from Milan (MXP) Fly for 1h 35m Arrive at 8:25am in Paris (CDG)

Layover in Paris for 0h 50m

Mon Jun 30th 2025 Air France · AF 1444 Depart at 9:15am from Paris (CDG) Fly for 1h 25m Arrive at 10:40am in Amsterdam (AMS)

Layover in Amsterdam for 2h 15m

Mon Jun 30th 2025 Air France · AF 8225 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)
US$1486

9:55pm - 11:45pm
Fri Jun 20th 2025

18h 50m
Panama (PTY) → Milan (MXP)

1 Stop

6:50am - 4:50pm
Mon Jun 30th 2025

17h 0m
Milan (MXP) → Panama (PTY)

2 Stops

Fri Jun 20th 2025 Turkish Airlines · TK 904 Depart at 9:55pm from Panama (PTY) Fly for 12h 45m Arrive at 6:40pm in Istanbul (IST)

Layover in Istanbul for 3h 10m

Sat Jun 21st 2025 Turkish Airlines · TK 1877 Depart at 9:50pm from Istanbul (IST) Fly for 2h 55m Arrive at 11:45pm in Milan (MXP)

Stay in Milan for 8 nights

Mon Jun 30th 2025 Air France · AF 1131 Depart at 6:50am from Milan (MXP) Fly for 1h 35m Arrive at 8:25am in Paris (CDG)

Layover in Paris for 0h 50m

Mon Jun 30th 2025 Air France · AF 1444 Depart at 9:15am from Paris (CDG) Fly for 1h 25m Arrive at 10:40am in Amsterdam (AMS)

Layover in Amsterdam for 2h 15m

Mon Jun 30th 2025 Air France · AF 8225 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)
US$1490

10:25am - 12:35pm
Fri Jun 20th 2025

19h 10m
Panama (PTY) → Rome (FCO)

2 Stops

7:05pm - 10:25am
Mon Jun 30th 2025

22h 20m
Rome (FCO) → Panama (PTY)

2 Stops

Fri Jun 20th 2025 Copa Airlines · CM 334 Depart at 10:25am from Panama (PTY) Fly for 3h 11m Arrive at 2:36pm in Miami (MIA)

Layover in Miami for 2h 39m

Fri Jun 20th 2025 Norse Atlantic UK · Z0 724 Depart at 5:15pm from Miami (MIA) Fly for 8h 40m Arrive at 6:55am in London (LGW)

Layover in London for 2h 5m

Sat Jun 21st 2025 easyJet · U2 8325 Depart at 9:00am from London (LGW) Fly for 2h 35m Arrive at 12:35pm in Rome (FCO)

Stay in Rome for 9 nights

Mon Jun 30th 2025 Norse Atlantic Airways · N0 401 Depart at 7:05pm from Rome (FCO) Fly for 9h 25m Arrive at 10:30pm in New York (JFK)

Layover in New York for 5h 5m

Tue Jul 1st 2025 Avianca · AV 571 Depart at 3:35am from New York (JFK) Fly for 4h 55m Arrive at 6:30am in San Salvador (SAL)

Layover in San Salvador for 1h 0m

Tue Jul 1st 2025 Avianca · AV 323 Depart at 7:30am from San Salvador (SAL) Fly for 1h 55m Arrive at 10:25am in Panama (PTY)
US$1492

8:25pm - 10:55pm
Fri Jun 20th 2025

19h 30m
Panama (PTY) → Florence (FLR)

2 Stops

6:50am - 3:40pm
Mon Jun 30th 2025

15h 50m
Florence (FLR) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 2h 35m

Sat Jun 21st 2025 Iberia Airlines · IB 435 Depart at 3:50pm from Madrid (MAD) Fly for 1h 5m Arrive at 4:55pm in Bilbao (BIO)

Layover in Bilbao for 3h 55m

Sat Jun 21st 2025 Volotea · V7 3556 Depart at 8:50pm from Bilbao (BIO) Fly for 2h 5m Arrive at 10:55pm in Florence (FLR)

Stay in Florence for 8 nights

Mon Jun 30th 2025 Vueling · VY 1494 Depart at 6:50am from Florence (FLR) Fly for 2h 25m Arrive at 9:15am in Madrid (MAD)

Layover in Madrid for 2h 45m

Mon Jun 30th 2025 Iberia Airlines · IB 257 Depart at 12:00pm from Madrid (MAD) Fly for 10h 40m Arrive at 3:40pm in Panama (PTY)
US$1496.40

8:25pm - 8:50pm
Fri Jun 20th 2025

17h 25m
Panama (PTY) → Rome (FCO)

1 Stop

10:00am - 5:45pm
Mon Jun 30th 2025

14h 45m
Rome (FCO) → Panama (PTY)

1 Stop

Fri Jun 20th 2025 Air Europa · UX 56 Depart at 8:25pm from Panama (PTY) Fly for 9h 50m Arrive at 1:15pm in Madrid (MAD)

Layover in Madrid for 5h 10m

Sat Jun 21st 2025 Ryanair · FR 2436 Depart at 6:25pm from Madrid (MAD) Fly for 2h 25m Arrive at 8:50pm in Rome (FCO)

Stay in Rome for 8 nights

Mon Jun 30th 2025 Air France · AF 1205 Depart at 10:00am from Rome (FCO) Fly for 2h 10m Arrive at 12:10pm in Paris (CDG)

Layover in Paris for 1h 45m

Mon Jun 30th 2025 Air France · AF 474 Depart at 1:55pm from Paris (CDG) Fly for 10h 50m Arrive at 5:45pm in Panama (PTY)

Sarah Belizaire

@sarahbb1

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John Ford

@eyupitsjohn

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Roaming Sonaa

@roamingsonaa

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Andy Travels

@andy_travels

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Travel With Bender

@travelwitbender

Did you spot my recent article about how to score cheap one way flights? ✈️ FlightList is my new secret tool for discovering cheap routes, within a departure date range. Plus you can also search by country/region for departures & destinations. Powerful! 💪

Wesley Mergard

@travel.with.wes

One useful tool I've found for evaluating different departure and return dates is called FlightList.io. You can quickly scan different travel date ranges, carriers and one way flight options to easily determine the cheapest flight combinations for your trip.

Flights from Panama City to Italy (PTY to IT)

Sarah Belizaire

John Ford

Roaming Sonaa

Andy Travels

Travel With Bender

Wesley Mergard

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