Cheap Flights from Madison to Knoxville (MSN to TYS)

Discover more affordable routes and cheaper dates from Madison to Knoxville (MSN to TYS) within a date range.

⭐ Search by country or region to discover more affordable routes, like Netherlands → Italy or Europe → South East Asia.

Results Quantity

Cabin Bags

Checked Bags

Max Budget

US$

Max Duration

Hours

Max Layover

Hours

Departure Time

Connections

Select Airlines

Loading…

US$596

6:40am - 1:21pm
Tue Jul 1st 2025

5h 41m
Madison (MSN) → Knoxville (TYS)

1 Stop

7:00am - 10:13am
Sat Jul 5th 2025

4h 13m
Knoxville (TYS) → Madison (MSN)

1 Stop

Tue Jul 1st 2025 United Airlines · UA 2137 Depart at 6:40am from Madison (MSN) Fly for 1h 8m Arrive at 7:48am in Chicago (ORD)

Layover in Chicago for 2h 47m

Tue Jul 1st 2025 United Airlines · UA 5836 Depart at 10:35am from Chicago (ORD) Fly for 1h 46m Arrive at 1:21pm in Knoxville (TYS)

Stay in Knoxville for 3 nights

Sat Jul 5th 2025 United Airlines · UA 1594 Depart at 7:00am from Knoxville (TYS) Fly for 1h 57m Arrive at 7:57am in Chicago (ORD)

Layover in Chicago for 1h 5m

Sat Jul 5th 2025 United Airlines · UA 5260 Depart at 9:02am from Chicago (ORD) Fly for 1h 11m Arrive at 10:13am in Madison (MSN)
US$647

10:55am - 5:05pm
Tue Jul 1st 2025

5h 10m
Madison (MSN) → Knoxville (TYS)

1 Stop

7:00am - 10:13am
Sat Jul 5th 2025

4h 13m
Knoxville (TYS) → Madison (MSN)

1 Stop

Tue Jul 1st 2025 United Airlines · UA 3644 Depart at 10:55am from Madison (MSN) Fly for 1h 10m Arrive at 12:05pm in Chicago (ORD)

Layover in Chicago for 2h 3m

Tue Jul 1st 2025 United Airlines · UA 5429 Depart at 2:08pm from Chicago (ORD) Fly for 1h 57m Arrive at 5:05pm in Knoxville (TYS)

Stay in Knoxville for 3 nights

Sat Jul 5th 2025 United Airlines · UA 1594 Depart at 7:00am from Knoxville (TYS) Fly for 1h 57m Arrive at 7:57am in Chicago (ORD)

Layover in Chicago for 1h 5m

Sat Jul 5th 2025 United Airlines · UA 5260 Depart at 9:02am from Chicago (ORD) Fly for 1h 11m Arrive at 10:13am in Madison (MSN)
US$696

12:18pm - 5:05pm
Tue Jul 1st 2025

3h 47m
Madison (MSN) → Knoxville (TYS)

1 Stop

7:00am - 10:13am
Sat Jul 5th 2025

4h 13m
Knoxville (TYS) → Madison (MSN)

1 Stop

Tue Jul 1st 2025 United Airlines · UA 4553 Depart at 12:18pm from Madison (MSN) Fly for 1h 9m Arrive at 1:27pm in Chicago (ORD)

Layover in Chicago for 0h 41m

Tue Jul 1st 2025 United Airlines · UA 5429 Depart at 2:08pm from Chicago (ORD) Fly for 1h 57m Arrive at 5:05pm in Knoxville (TYS)

Stay in Knoxville for 3 nights

Sat Jul 5th 2025 United Airlines · UA 1594 Depart at 7:00am from Knoxville (TYS) Fly for 1h 57m Arrive at 7:57am in Chicago (ORD)

Layover in Chicago for 1h 5m

Sat Jul 5th 2025 United Airlines · UA 5260 Depart at 9:02am from Chicago (ORD) Fly for 1h 11m Arrive at 10:13am in Madison (MSN)
US$856

10:55am - 5:05pm
Tue Jul 1st 2025

5h 10m
Madison (MSN) → Knoxville (TYS)

1 Stop

5:46pm - 8:58pm
Sat Jul 5th 2025

4h 12m
Knoxville (TYS) → Madison (MSN)

1 Stop

Tue Jul 1st 2025 United Airlines · UA 3644 Depart at 10:55am from Madison (MSN) Fly for 1h 10m Arrive at 12:05pm in Chicago (ORD)

Layover in Chicago for 2h 3m

Tue Jul 1st 2025 United Airlines · UA 5429 Depart at 2:08pm from Chicago (ORD) Fly for 1h 57m Arrive at 5:05pm in Knoxville (TYS)

Stay in Knoxville for 4 nights

Sat Jul 5th 2025 United Airlines · UA 5767 Depart at 5:46pm from Knoxville (TYS) Fly for 2h 4m Arrive at 6:50pm in Chicago (ORD)

Layover in Chicago for 0h 55m

Sat Jul 5th 2025 United Airlines · UA 3604 Depart at 7:45pm from Chicago (ORD) Fly for 1h 13m Arrive at 8:58pm in Madison (MSN)
US$856

6:40am - 1:21pm
Tue Jul 1st 2025

5h 41m
Madison (MSN) → Knoxville (TYS)

1 Stop

5:46pm - 8:58pm
Sat Jul 5th 2025

4h 12m
Knoxville (TYS) → Madison (MSN)

1 Stop

Tue Jul 1st 2025 United Airlines · UA 2137 Depart at 6:40am from Madison (MSN) Fly for 1h 8m Arrive at 7:48am in Chicago (ORD)

Layover in Chicago for 2h 47m

Tue Jul 1st 2025 United Airlines · UA 5836 Depart at 10:35am from Chicago (ORD) Fly for 1h 46m Arrive at 1:21pm in Knoxville (TYS)

Stay in Knoxville for 4 nights

Sat Jul 5th 2025 United Airlines · UA 5767 Depart at 5:46pm from Knoxville (TYS) Fly for 2h 4m Arrive at 6:50pm in Chicago (ORD)

Layover in Chicago for 0h 55m

Sat Jul 5th 2025 United Airlines · UA 3604 Depart at 7:45pm from Chicago (ORD) Fly for 1h 13m Arrive at 8:58pm in Madison (MSN)
US$894

8:10am - 1:21pm
Tue Jul 1st 2025

4h 11m
Madison (MSN) → Knoxville (TYS)

1 Stop

5:46pm - 10:30pm
Sat Jul 5th 2025

5h 44m
Knoxville (TYS) → Madison (MSN)

1 Stop

Tue Jul 1st 2025 United Airlines · UA 3672 Depart at 8:10am from Madison (MSN) Fly for 1h 10m Arrive at 9:20am in Chicago (ORD)

Layover in Chicago for 1h 15m

Tue Jul 1st 2025 United Airlines · UA 5836 Depart at 10:35am from Chicago (ORD) Fly for 1h 46m Arrive at 1:21pm in Knoxville (TYS)

Stay in Knoxville for 4 nights

Sat Jul 5th 2025 United Airlines · UA 5767 Depart at 5:46pm from Knoxville (TYS) Fly for 2h 4m Arrive at 6:50pm in Chicago (ORD)

Layover in Chicago for 2h 30m

Sat Jul 5th 2025 United Airlines · UA 630 Depart at 9:20pm from Chicago (ORD) Fly for 1h 10m Arrive at 10:30pm in Madison (MSN)
US$926

10:55am - 5:05pm
Tue Jul 1st 2025

5h 10m
Madison (MSN) → Knoxville (TYS)

1 Stop

5:46pm - 10:30pm
Sat Jul 5th 2025

5h 44m
Knoxville (TYS) → Madison (MSN)

1 Stop

Tue Jul 1st 2025 United Airlines · UA 3644 Depart at 10:55am from Madison (MSN) Fly for 1h 10m Arrive at 12:05pm in Chicago (ORD)

Layover in Chicago for 2h 3m

Tue Jul 1st 2025 United Airlines · UA 5429 Depart at 2:08pm from Chicago (ORD) Fly for 1h 57m Arrive at 5:05pm in Knoxville (TYS)

Stay in Knoxville for 4 nights

Sat Jul 5th 2025 United Airlines · UA 5767 Depart at 5:46pm from Knoxville (TYS) Fly for 2h 4m Arrive at 6:50pm in Chicago (ORD)

Layover in Chicago for 2h 30m

Sat Jul 5th 2025 United Airlines · UA 630 Depart at 9:20pm from Chicago (ORD) Fly for 1h 10m Arrive at 10:30pm in Madison (MSN)
US$974

12:18pm - 5:05pm
Tue Jul 1st 2025

3h 47m
Madison (MSN) → Knoxville (TYS)

1 Stop

5:46pm - 10:30pm
Sat Jul 5th 2025

5h 44m
Knoxville (TYS) → Madison (MSN)

1 Stop

Tue Jul 1st 2025 United Airlines · UA 4553 Depart at 12:18pm from Madison (MSN) Fly for 1h 9m Arrive at 1:27pm in Chicago (ORD)

Layover in Chicago for 0h 41m

Tue Jul 1st 2025 United Airlines · UA 5429 Depart at 2:08pm from Chicago (ORD) Fly for 1h 57m Arrive at 5:05pm in Knoxville (TYS)

Stay in Knoxville for 4 nights

Sat Jul 5th 2025 United Airlines · UA 5767 Depart at 5:46pm from Knoxville (TYS) Fly for 2h 4m Arrive at 6:50pm in Chicago (ORD)

Layover in Chicago for 2h 30m

Sat Jul 5th 2025 United Airlines · UA 630 Depart at 9:20pm from Chicago (ORD) Fly for 1h 10m Arrive at 10:30pm in Madison (MSN)

Sarah Belizaire

@sarahbb1

Have flexible travel plans or looking for alternative routes given the chaos? Check out all the connection possibilities via a super helpful site created by @ismaelyws flightlist.io thanks to @andy_travels for the recommendation #travel #flights

John Ford

@eyupitsjohn

There seem to be lots of sites launching at the moment that promise to find you cheap flights but not many have the professional finish of Flightlist by @ismaelyws #travel #flights

Roaming Sonaa

@roamingsonaa

For people wanting to maximize their trips, Flightlist is my newest travel hack for uncovering the coolest routes at irresistible prices. No stress, no annoying ads — just seamless flight booking with amazing functionality. It's designed for remote workers, backpackers, and people living abroad.

Read Sonaa's 7 Amazing Skyscanner Alternatives for Booking Travel

ANDY TRAVELS

@andy_travels

@ismaelyws Just tried out Flightlist for the first time. Really nice idea, well made, and just what I need at the moment 👍

Travel With Bender

@travelwitbender

Did you spot my recent article about how to score cheap one way flights? ✈️ FlightList is my new secret tool for discovering cheap routes, within a departure date range. Plus you can also search by country/region for departures & destinations. Powerful! 💪

Read Josh's Ultimate Guide To Find Cheap One Way Flights

Wesley Mergard

@travel.with.wes

One useful tool I've found for evaluating different departure and return dates is called FlightList.io. You can quickly scan different travel date ranges, carriers and one way flight options to easily determine the cheapest flight combinations for your trip.

Read Wesley's My Best Cheap Flight Hacks (Why Pay More?)

Cheap Flights from Madison to Knoxville (MSN to TYS)

Sarah Belizaire

John Ford

Roaming Sonaa

ANDY TRAVELS

Travel With Bender

Wesley Mergard

Latest Cheap Flight Searches

FlightList Blog

Flightlist Interviews 7 Travel Experts On Why They Book One Way Flights

Why I Built FlightList & Solved My Own Problem

About FlightList