Flights from Lisbon to Santiago (LIS to SCL)

Discover more affordable routes and cheaper dates from Lisbon to Santiago (LIS to SCL) within a date range.

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US$804

9:25am - 1:50pm
Fri Sep 26th 2025

32h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 17h 45m

Sat Sep 27th 2025 JetSMART · JA 771 Depart at 9:20am from São Paulo (GRU) Fly for 4h 30m Arrive at 1:50pm in Santiago de Chile (SCL)
US$835.50

9:25am - 2:50pm
Fri Sep 26th 2025

33h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 18h 50m

Sat Sep 27th 2025 Sky Airline · H2 651 Depart at 10:25am from São Paulo (GRU) Fly for 4h 25m Arrive at 2:50pm in Santiago de Chile (SCL)
US$847.50

9:25am - 10:40pm
Fri Sep 26th 2025

17h 15m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 3h 40m

Fri Sep 26th 2025 Sky Airline · H2 611 Depart at 7:15pm from São Paulo (GRU) Fly for 3h 25m Arrive at 10:40pm in Santiago de Chile (SCL)
US$858.82

9:25am - 12:30am
Fri Sep 26th 2025

19h 5m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 4h 35m

Fri Sep 26th 2025 LATAM Airlines · LA 755 Depart at 8:10pm from São Paulo (GRU) Fly for 4h 20m Arrive at 12:30am in Santiago de Chile (SCL)
US$858.82

9:25am - 12:55pm
Fri Sep 26th 2025

31h 30m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 17h 0m

Sat Sep 27th 2025 LATAM Airlines · LA 605 Depart at 8:35am from São Paulo (GRU) Fly for 4h 20m Arrive at 12:55pm in Santiago de Chile (SCL)
US$858.82

9:25am - 5:55pm
Fri Sep 26th 2025

36h 30m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 21h 55m

Sat Sep 27th 2025 LATAM Airlines · LA 8036 Depart at 1:30pm from São Paulo (GRU) Fly for 4h 25m Arrive at 5:55pm in Santiago de Chile (SCL)
US$872.82

9:25am - 3:15pm
Fri Sep 26th 2025

33h 50m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 19h 15m

Sat Sep 27th 2025 LATAM Airlines · LA 8104 Depart at 10:50am from São Paulo (GRU) Fly for 4h 25m Arrive at 3:15pm in Santiago de Chile (SCL)
US$872.82

9:25am - 6:50pm
Fri Sep 26th 2025

37h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 22h 55m

Sat Sep 27th 2025 LATAM Airlines · LA 763 Depart at 2:30pm from São Paulo (GRU) Fly for 4h 20m Arrive at 6:50pm in Santiago de Chile (SCL)
US$872.82

9:25am - 8:35pm
Fri Sep 26th 2025

39h 10m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 24h 40m

Sat Sep 27th 2025 LATAM Airlines · LA 8096 Depart at 4:15pm from São Paulo (GRU) Fly for 4h 20m Arrive at 8:35pm in Santiago de Chile (SCL)
US$902.82

9:25am - 11:30am
Fri Sep 26th 2025

30h 5m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 15h 35m

Sat Sep 27th 2025 LATAM Airlines · LA 715 Depart at 7:10am from São Paulo (GRU) Fly for 4h 20m Arrive at 11:30am in Santiago de Chile (SCL)
US$928.82

9:25am - 2:30am
Fri Sep 26th 2025

21h 5m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 6h 35m

Fri Sep 26th 2025 LATAM Airlines · LA 749 Depart at 10:10pm from São Paulo (GRU) Fly for 4h 20m Arrive at 2:30am in Santiago de Chile (SCL)
US$928.82

9:25am - 4:00am
Fri Sep 26th 2025

22h 35m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 8h 5m

Fri Sep 26th 2025 LATAM Airlines · LA 8030 Depart at 11:40pm from São Paulo (GRU) Fly for 4h 20m Arrive at 4:00am in Santiago de Chile (SCL)
US$934

9:25am - 3:50pm
Sat Sep 27th 2025

34h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 19h 45m

Sun Sep 28th 2025 JetSMART · JA 771 Depart at 11:20am from São Paulo (GRU) Fly for 4h 30m Arrive at 3:50pm in Santiago de Chile (SCL)
US$972.82

9:25am - 10:55pm
Sat Sep 27th 2025

17h 30m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 3h 0m

Sat Sep 27th 2025 LATAM Airlines · LA 753 Depart at 6:35pm from São Paulo (GRU) Fly for 4h 20m Arrive at 10:55pm in Santiago de Chile (SCL)
US$987.82

9:25am - 12:55pm
Sat Sep 27th 2025

31h 30m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 17h 0m

Sun Sep 28th 2025 LATAM Airlines · LA 605 Depart at 8:35am from São Paulo (GRU) Fly for 4h 20m Arrive at 12:55pm in Santiago de Chile (SCL)
US$987.82

9:25am - 3:15pm
Sat Sep 27th 2025

33h 50m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 19h 15m

Sun Sep 28th 2025 LATAM Airlines · LA 8104 Depart at 10:50am from São Paulo (GRU) Fly for 4h 25m Arrive at 3:15pm in Santiago de Chile (SCL)
US$990.82

9:25am - 1:45am
Fri Sep 26th 2025

20h 20m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 5h 50m

Fri Sep 26th 2025 LATAM Airlines · LA 751 Depart at 9:25pm from São Paulo (GRU) Fly for 4h 20m Arrive at 1:45am in Santiago de Chile (SCL)
US$1013.49

4:20pm - 1:05pm
Fri Sep 26th 2025

24h 45m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 109 Depart at 4:20pm from Lisbon (LIS) Fly for 11h 5m Arrive at 11:25pm in Florianópolis (FLN)

Layover in Florianópolis for 9h 50m

Sat Sep 27th 2025 Sky Airline · H2 633 Depart at 9:15am from Florianópolis (FLN) Fly for 3h 50m Arrive at 1:05pm in Santiago de Chile (SCL)
US$1017.49

5:05pm - 1:50pm
Fri Sep 26th 2025

24h 45m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 83 Depart at 5:05pm from Lisbon (LIS) Fly for 10h 10m Arrive at 11:15pm in São Paulo (GRU)

Layover in São Paulo for 10h 5m

Sat Sep 27th 2025 JetSMART · JA 771 Depart at 9:20am from São Paulo (GRU) Fly for 4h 30m Arrive at 1:50pm in Santiago de Chile (SCL)
US$1037.49

4:20pm - 2:15pm
Fri Sep 26th 2025

25h 55m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 109 Depart at 4:20pm from Lisbon (LIS) Fly for 11h 5m Arrive at 11:25pm in Florianópolis (FLN)

Layover in Florianópolis for 11h 5m

Sat Sep 27th 2025 LATAM Airlines · LA 719 Depart at 10:30am from Florianópolis (FLN) Fly for 3h 45m Arrive at 2:15pm in Santiago de Chile (SCL)
US$1037.49

4:20pm - 7:25pm
Fri Sep 26th 2025

31h 5m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 109 Depart at 4:20pm from Lisbon (LIS) Fly for 11h 5m Arrive at 11:25pm in Florianópolis (FLN)

Layover in Florianópolis for 16h 15m

Sat Sep 27th 2025 LATAM Airlines · LA 511 Depart at 3:40pm from Florianópolis (FLN) Fly for 3h 45m Arrive at 7:25pm in Santiago de Chile (SCL)
US$1043.82

9:25am - 4:00am
Sat Sep 27th 2025

22h 35m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 8h 5m

Sat Sep 27th 2025 LATAM Airlines · LA 8030 Depart at 11:40pm from São Paulo (GRU) Fly for 4h 20m Arrive at 4:00am in Santiago de Chile (SCL)
US$1052.49

5:05pm - 2:50pm
Fri Sep 26th 2025

25h 45m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 83 Depart at 5:05pm from Lisbon (LIS) Fly for 10h 10m Arrive at 11:15pm in São Paulo (GRU)

Layover in São Paulo for 11h 10m

Sat Sep 27th 2025 Sky Airline · H2 651 Depart at 10:25am from São Paulo (GRU) Fly for 4h 25m Arrive at 2:50pm in Santiago de Chile (SCL)
US$1067.49

5:05pm - 12:55pm
Fri Sep 26th 2025

23h 50m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 83 Depart at 5:05pm from Lisbon (LIS) Fly for 10h 10m Arrive at 11:15pm in São Paulo (GRU)

Layover in São Paulo for 9h 20m

Sat Sep 27th 2025 LATAM Airlines · LA 605 Depart at 8:35am from São Paulo (GRU) Fly for 4h 20m Arrive at 12:55pm in Santiago de Chile (SCL)
US$1067.49

5:05pm - 5:55pm
Fri Sep 26th 2025

28h 50m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 83 Depart at 5:05pm from Lisbon (LIS) Fly for 10h 10m Arrive at 11:15pm in São Paulo (GRU)

Layover in São Paulo for 14h 15m

Sat Sep 27th 2025 LATAM Airlines · LA 8036 Depart at 1:30pm from São Paulo (GRU) Fly for 4h 25m Arrive at 5:55pm in Santiago de Chile (SCL)
US$1082.49

5:05pm - 3:15pm
Fri Sep 26th 2025

26h 10m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 83 Depart at 5:05pm from Lisbon (LIS) Fly for 10h 10m Arrive at 11:15pm in São Paulo (GRU)

Layover in São Paulo for 11h 35m

Sat Sep 27th 2025 LATAM Airlines · LA 8104 Depart at 10:50am from São Paulo (GRU) Fly for 4h 25m Arrive at 3:15pm in Santiago de Chile (SCL)
US$1104.82

9:25am - 12:30am
Sat Sep 27th 2025

19h 5m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 LATAM Airlines · LA 8147 Depart at 9:25am from Lisbon (LIS) Fly for 10h 10m Arrive at 3:35pm in São Paulo (GRU)

Layover in São Paulo for 4h 35m

Sat Sep 27th 2025 LATAM Airlines · LA 755 Depart at 8:10pm from São Paulo (GRU) Fly for 4h 20m Arrive at 12:30am in Santiago de Chile (SCL)
US$1112.49

5:05pm - 11:30am
Fri Sep 26th 2025

22h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 83 Depart at 5:05pm from Lisbon (LIS) Fly for 10h 10m Arrive at 11:15pm in São Paulo (GRU)

Layover in São Paulo for 7h 55m

Sat Sep 27th 2025 LATAM Airlines · LA 715 Depart at 7:10am from São Paulo (GRU) Fly for 4h 20m Arrive at 11:30am in Santiago de Chile (SCL)
US$1119.49

10:15am - 11:25pm
Fri Sep 26th 2025

17h 10m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 103 Depart at 10:15am from Lisbon (LIS) Fly for 9h 35m Arrive at 3:50pm in Belo Horizonte (CNF)

Layover in Belo Horizonte for 2h 40m

Fri Sep 26th 2025 LATAM Airlines · LA 673 Depart at 6:30pm from Belo Horizonte (CNF) Fly for 4h 55m Arrive at 11:25pm in Santiago de Chile (SCL)
US$1189.49

12:25pm - 3:50pm
Sat Sep 27th 2025

31h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 89 Depart at 12:25pm from Lisbon (LIS) Fly for 10h 10m Arrive at 6:35pm in São Paulo (GRU)

Layover in São Paulo for 16h 45m

Sun Sep 28th 2025 JetSMART · JA 771 Depart at 11:20am from São Paulo (GRU) Fly for 4h 30m Arrive at 3:50pm in Santiago de Chile (SCL)
US$1208.49

1:10pm - 2:30am
Fri Sep 26th 2025

17h 20m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 89 Depart at 1:10pm from Lisbon (LIS) Fly for 10h 5m Arrive at 7:15pm in São Paulo (GRU)

Layover in São Paulo for 2h 55m

Fri Sep 26th 2025 LATAM Airlines · LA 749 Depart at 10:10pm from São Paulo (GRU) Fly for 4h 20m Arrive at 2:30am in Santiago de Chile (SCL)
US$1212.49

10:35am - 6:59am
Sat Sep 27th 2025

24h 24m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 223 Depart at 10:35am from Lisbon (LIS) Fly for 9h 10m Arrive at 2:45pm in Miami (MIA)

Layover in Miami for 7h 14m

Sat Sep 27th 2025 LATAM Airlines · LA 501 Depart at 9:59pm from Miami (MIA) Fly for 8h 0m Arrive at 6:59am in Santiago de Chile (SCL)
US$1229.49

3:15pm - 12:10am
Sat Sep 27th 2025

36h 55m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 117 Depart at 3:15pm from Lisbon (LIS) Fly for 11h 20m Arrive at 10:35pm in Porto Alegre (POA)

Layover in Porto Alegre for 22h 20m

Sun Sep 28th 2025 LATAM Airlines · LA 741 Depart at 8:55pm from Porto Alegre (POA) Fly for 3h 15m Arrive at 12:10am in Santiago de Chile (SCL)
US$1237.49

12:25pm - 12:55pm
Sat Sep 27th 2025

28h 30m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 89 Depart at 12:25pm from Lisbon (LIS) Fly for 10h 10m Arrive at 6:35pm in São Paulo (GRU)

Layover in São Paulo for 14h 0m

Sun Sep 28th 2025 LATAM Airlines · LA 605 Depart at 8:35am from São Paulo (GRU) Fly for 4h 20m Arrive at 12:55pm in Santiago de Chile (SCL)
US$1248.49

5:20pm - 9:50pm
Sat Sep 27th 2025

32h 30m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 29 Depart at 5:20pm from Lisbon (LIS) Fly for 8h 35m Arrive at 9:55pm in Salvador (SSA)

Layover in Salvador for 15h 35m

Sun Sep 28th 2025 Sky Airline · H2 1681 Depart at 1:30pm from Salvador (SSA) Fly for 8h 20m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1269.49

1:10pm - 1:45am
Fri Sep 26th 2025

16h 35m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 89 Depart at 1:10pm from Lisbon (LIS) Fly for 10h 5m Arrive at 7:15pm in São Paulo (GRU)

Layover in São Paulo for 2h 10m

Fri Sep 26th 2025 LATAM Airlines · LA 751 Depart at 9:25pm from São Paulo (GRU) Fly for 4h 20m Arrive at 1:45am in Santiago de Chile (SCL)
US$1293.49

12:25pm - 4:00am
Sat Sep 27th 2025

19h 35m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 89 Depart at 12:25pm from Lisbon (LIS) Fly for 10h 10m Arrive at 6:35pm in São Paulo (GRU)

Layover in São Paulo for 5h 5m

Sat Sep 27th 2025 LATAM Airlines · LA 8030 Depart at 11:40pm from São Paulo (GRU) Fly for 4h 20m Arrive at 4:00am in Santiago de Chile (SCL)
US$1303.27

8:30pm - 9:35pm
Sat Sep 27th 2025

29h 5m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 Ryanair · FR 9743 Depart at 8:30pm from Lisbon (LIS) Fly for 1h 20m Arrive at 10:50pm in Madrid (MAD)

Layover in Madrid for 14h 30m

Sun Sep 28th 2025 Iberia Airlines · IB 113 Depart at 1:20pm from Madrid (MAD) Fly for 13h 15m Arrive at 9:35pm in Santiago de Chile (SCL)
US$1344.49

5:05pm - 3:50pm
Sat Sep 27th 2025

26h 45m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 83 Depart at 5:05pm from Lisbon (LIS) Fly for 10h 10m Arrive at 11:15pm in São Paulo (GRU)

Layover in São Paulo for 12h 5m

Sun Sep 28th 2025 JetSMART · JA 771 Depart at 11:20am from São Paulo (GRU) Fly for 4h 30m Arrive at 3:50pm in Santiago de Chile (SCL)
US$1393.49

12:25pm - 1:45am
Sat Sep 27th 2025

17h 20m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 89 Depart at 12:25pm from Lisbon (LIS) Fly for 10h 10m Arrive at 6:35pm in São Paulo (GRU)

Layover in São Paulo for 2h 50m

Sat Sep 27th 2025 LATAM Airlines · LA 751 Depart at 9:25pm from São Paulo (GRU) Fly for 4h 20m Arrive at 1:45am in Santiago de Chile (SCL)
US$1393.49

5:05pm - 12:55pm
Sat Sep 27th 2025

23h 50m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 83 Depart at 5:05pm from Lisbon (LIS) Fly for 10h 10m Arrive at 11:15pm in São Paulo (GRU)

Layover in São Paulo for 9h 20m

Sun Sep 28th 2025 LATAM Airlines · LA 605 Depart at 8:35am from São Paulo (GRU) Fly for 4h 20m Arrive at 12:55pm in Santiago de Chile (SCL)
US$1399.50

7:05am - 9:50pm
Fri Sep 26th 2025

18h 45m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 easyJet · U2 7651 Depart at 7:05am from Lisbon (LIS) Fly for 1h 15m Arrive at 9:20am in Madrid (MAD)

Layover in Madrid for 4h 5m

Fri Sep 26th 2025 LATAM Airlines · LA 707 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1405.49

7:40am - 9:50pm
Fri Sep 26th 2025

18h 10m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 Air Europa · UX 1152 Depart at 7:40am from Lisbon (LIS) Fly for 1h 15m Arrive at 9:55am in Madrid (MAD)

Layover in Madrid for 3h 30m

Fri Sep 26th 2025 LATAM Airlines · LA 707 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1420.61

7:55am - 9:50pm
Fri Sep 26th 2025

17h 55m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 1010 Depart at 7:55am from Lisbon (LIS) Fly for 1h 20m Arrive at 10:15am in Madrid (MAD)

Layover in Madrid for 3h 10m

Fri Sep 26th 2025 LATAM Airlines · LA 707 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1425.64

8:25am - 9:50pm
Fri Sep 26th 2025

17h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 Iberia Airlines · IB 530 Depart at 8:25am from Lisbon (LIS) Fly for 1h 25m Arrive at 10:50am in Madrid (MAD)

Layover in Madrid for 2h 35m

Fri Sep 26th 2025 LATAM Airlines · LA 707 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1449.49

5:05pm - 11:30am
Sat Sep 27th 2025

22h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 83 Depart at 5:05pm from Lisbon (LIS) Fly for 10h 10m Arrive at 11:15pm in São Paulo (GRU)

Layover in São Paulo for 7h 55m

Sun Sep 28th 2025 LATAM Airlines · LA 715 Depart at 7:10am from São Paulo (GRU) Fly for 4h 20m Arrive at 11:30am in Santiago de Chile (SCL)
US$1484.93

6:35am - 9:35pm
Fri Sep 26th 2025

19h 0m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 Iberia Airlines · IB 540 Depart at 6:35am from Lisbon (LIS) Fly for 1h 25m Arrive at 9:00am in Madrid (MAD)

Layover in Madrid for 4h 20m

Fri Sep 26th 2025 Iberia Airlines · IB 113 Depart at 1:20pm from Madrid (MAD) Fly for 13h 15m Arrive at 9:35pm in Santiago de Chile (SCL)
US$1487.93

4:45pm - 9:35pm
Sat Sep 27th 2025

32h 50m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 Iberia Airlines · IB 1144 Depart at 4:45pm from Lisbon (LIS) Fly for 1h 25m Arrive at 7:10pm in Madrid (MAD)

Layover in Madrid for 18h 10m

Sun Sep 28th 2025 Iberia Airlines · IB 113 Depart at 1:20pm from Madrid (MAD) Fly for 13h 15m Arrive at 9:35pm in Santiago de Chile (SCL)
US$1497.79

7:05am - 9:35pm
Fri Sep 26th 2025

18h 30m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 easyJet · U2 7651 Depart at 7:05am from Lisbon (LIS) Fly for 1h 15m Arrive at 9:20am in Madrid (MAD)

Layover in Madrid for 4h 0m

Fri Sep 26th 2025 Iberia Airlines · IB 113 Depart at 1:20pm from Madrid (MAD) Fly for 13h 15m Arrive at 9:35pm in Santiago de Chile (SCL)
US$1503.78

7:40am - 9:35pm
Fri Sep 26th 2025

17h 55m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 Air Europa · UX 1152 Depart at 7:40am from Lisbon (LIS) Fly for 1h 15m Arrive at 9:55am in Madrid (MAD)

Layover in Madrid for 3h 25m

Fri Sep 26th 2025 Iberia Airlines · IB 113 Depart at 1:20pm from Madrid (MAD) Fly for 13h 15m Arrive at 9:35pm in Santiago de Chile (SCL)
US$1506.91

10:00pm - 9:35pm
Sat Sep 27th 2025

27h 35m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 1022 Depart at 10:00pm from Lisbon (LIS) Fly for 1h 20m Arrive at 12:20am in Madrid (MAD)

Layover in Madrid for 13h 0m

Sun Sep 28th 2025 Iberia Airlines · IB 113 Depart at 1:20pm from Madrid (MAD) Fly for 13h 15m Arrive at 9:35pm in Santiago de Chile (SCL)
US$1518.91

7:55am - 9:35pm
Fri Sep 26th 2025

17h 40m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 1010 Depart at 7:55am from Lisbon (LIS) Fly for 1h 20m Arrive at 10:15am in Madrid (MAD)

Layover in Madrid for 3h 5m

Fri Sep 26th 2025 Iberia Airlines · IB 113 Depart at 1:20pm from Madrid (MAD) Fly for 13h 15m Arrive at 9:35pm in Santiago de Chile (SCL)
US$1522.93

8:25am - 9:35pm
Fri Sep 26th 2025

17h 10m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 Iberia Airlines · IB 530 Depart at 8:25am from Lisbon (LIS) Fly for 1h 25m Arrive at 10:50am in Madrid (MAD)

Layover in Madrid for 2h 30m

Fri Sep 26th 2025 Iberia Airlines · IB 113 Depart at 1:20pm from Madrid (MAD) Fly for 13h 15m Arrive at 9:35pm in Santiago de Chile (SCL)
US$1539.80

8:10pm - 8:35am
Fri Sep 26th 2025

40h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 TAP Portugal · TP 1366 Depart at 8:10pm from Lisbon (LIS) Fly for 2h 45m Arrive at 10:55pm in London (LHR)

Layover in London for 23h 0m

Sat Sep 27th 2025 British Airways · BA 251 Depart at 9:55pm from London (LHR) Fly for 14h 40m Arrive at 8:35am in Santiago de Chile (SCL)
US$1569.80

4:05pm - 8:35am
Sat Sep 27th 2025

20h 30m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 1364 Depart at 4:05pm from Lisbon (LIS) Fly for 2h 45m Arrive at 6:50pm in London (LHR)

Layover in London for 3h 5m

Sat Sep 27th 2025 British Airways · BA 251 Depart at 9:55pm from London (LHR) Fly for 14h 40m Arrive at 8:35am in Santiago de Chile (SCL)
US$1598.93

7:05pm - 8:24am
Fri Sep 26th 2025

17h 19m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 Iberia Airlines · IB 536 Depart at 7:05pm from Lisbon (LIS) Fly for 1h 25m Arrive at 9:30pm in Madrid (MAD)

Layover in Madrid for 2h 29m

Fri Sep 26th 2025 Iberia Airlines · IB 117 Depart at 11:59pm from Madrid (MAD) Fly for 13h 25m Arrive at 8:24am in Santiago de Chile (SCL)
US$1617.79

6:50pm - 8:24am
Fri Sep 26th 2025

17h 34m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 easyJet · U2 6723 Depart at 6:50pm from Lisbon (LIS) Fly for 1h 30m Arrive at 9:20pm in Madrid (MAD)

Layover in Madrid for 2h 39m

Fri Sep 26th 2025 Iberia Airlines · IB 117 Depart at 11:59pm from Madrid (MAD) Fly for 13h 25m Arrive at 8:24am in Santiago de Chile (SCL)
US$1785.43

11:45am - 8:15pm
Sat Sep 27th 2025

36h 30m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 73 Depart at 11:45am from Lisbon (LIS) Fly for 9h 55m Arrive at 5:40pm in Rio de Janeiro (GIG)

Layover in Rio de Janeiro for 21h 40m

Sun Sep 28th 2025 Sky Airline · H2 623 Depart at 3:20pm from Rio de Janeiro (GIG) Fly for 4h 55m Arrive at 8:15pm in Santiago de Chile (SCL)
US$1801.50

7:05am - 9:50pm
Sat Sep 27th 2025

18h 45m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 easyJet · U2 7651 Depart at 7:05am from Lisbon (LIS) Fly for 1h 15m Arrive at 9:20am in Madrid (MAD)

Layover in Madrid for 4h 5m

Sat Sep 27th 2025 LATAM Airlines · LA 707 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1822.61

7:55am - 9:50pm
Sat Sep 27th 2025

17h 55m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 1010 Depart at 7:55am from Lisbon (LIS) Fly for 1h 20m Arrive at 10:15am in Madrid (MAD)

Layover in Madrid for 3h 10m

Sat Sep 27th 2025 LATAM Airlines · LA 707 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1832.49

7:40am - 9:50pm
Sat Sep 27th 2025

18h 10m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 Air Europa · UX 1152 Depart at 7:40am from Lisbon (LIS) Fly for 1h 15m Arrive at 9:55am in Madrid (MAD)

Layover in Madrid for 3h 30m

Sat Sep 27th 2025 LATAM Airlines · LA 707 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1894.64

8:25am - 9:50pm
Sat Sep 27th 2025

17h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 Iberia Airlines · IB 530 Depart at 8:25am from Lisbon (LIS) Fly for 1h 25m Arrive at 10:50am in Madrid (MAD)

Layover in Madrid for 2h 35m

Sat Sep 27th 2025 LATAM Airlines · LA 707 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1944

5:05pm - 8:50am
Sat Sep 27th 2025

19h 45m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 83 Depart at 5:05pm from Lisbon (LIS) Fly for 10h 10m Arrive at 11:15pm in São Paulo (GRU)

Layover in São Paulo for 5h 20m

Sun Sep 28th 2025 Turkish Airlines · TK 215 Depart at 4:35am from São Paulo (GRU) Fly for 4h 15m Arrive at 8:50am in Santiago de Chile (SCL)
US$1948.64

6:35am - 9:50pm
Sat Sep 27th 2025

19h 15m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 Iberia Airlines · IB 540 Depart at 6:35am from Lisbon (LIS) Fly for 1h 25m Arrive at 9:00am in Madrid (MAD)

Layover in Madrid for 4h 25m

Sat Sep 27th 2025 Iberia Airlines · IB 6651 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1954.50

7:05am - 9:50pm
Sat Sep 27th 2025

18h 45m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 easyJet · U2 7651 Depart at 7:05am from Lisbon (LIS) Fly for 1h 15m Arrive at 9:20am in Madrid (MAD)

Layover in Madrid for 4h 5m

Sat Sep 27th 2025 Iberia Airlines · IB 6651 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1975.61

7:55am - 9:50pm
Sat Sep 27th 2025

17h 55m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 1010 Depart at 7:55am from Lisbon (LIS) Fly for 1h 20m Arrive at 10:15am in Madrid (MAD)

Layover in Madrid for 3h 10m

Sat Sep 27th 2025 Iberia Airlines · IB 6651 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$1995.93

4:45pm - 8:24am
Sat Sep 27th 2025

19h 39m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 Iberia Airlines · IB 1144 Depart at 4:45pm from Lisbon (LIS) Fly for 1h 25m Arrive at 7:10pm in Madrid (MAD)

Layover in Madrid for 4h 49m

Sat Sep 27th 2025 Iberia Airlines · IB 117 Depart at 11:59pm from Madrid (MAD) Fly for 13h 25m Arrive at 8:24am in Santiago de Chile (SCL)
US$2001

7:05pm - 8:24am
Sat Sep 27th 2025

17h 19m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 1020 Depart at 7:05pm from Lisbon (LIS) Fly for 1h 20m Arrive at 9:25pm in Madrid (MAD)

Layover in Madrid for 2h 34m

Sat Sep 27th 2025 Iberia Airlines · IB 117 Depart at 11:59pm from Madrid (MAD) Fly for 13h 25m Arrive at 8:24am in Santiago de Chile (SCL)
US$2047.64

8:25am - 9:50pm
Sat Sep 27th 2025

17h 25m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 Iberia Airlines · IB 530 Depart at 8:25am from Lisbon (LIS) Fly for 1h 25m Arrive at 10:50am in Madrid (MAD)

Layover in Madrid for 2h 35m

Sat Sep 27th 2025 Iberia Airlines · IB 6651 Depart at 1:25pm from Madrid (MAD) Fly for 13h 25m Arrive at 9:50pm in Santiago de Chile (SCL)
US$2233.64

7:05pm - 8:20am
Fri Sep 26th 2025

17h 15m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 Iberia Airlines · IB 536 Depart at 7:05pm from Lisbon (LIS) Fly for 1h 25m Arrive at 9:30pm in Madrid (MAD)

Layover in Madrid for 2h 25m

Fri Sep 26th 2025 Iberia Airlines · IB 6586 Depart at 11:55pm from Madrid (MAD) Fly for 13h 25m Arrive at 8:20am in Santiago de Chile (SCL)
US$2250.64

4:45pm - 8:20am
Sat Sep 27th 2025

19h 35m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 Iberia Airlines · IB 1144 Depart at 4:45pm from Lisbon (LIS) Fly for 1h 25m Arrive at 7:10pm in Madrid (MAD)

Layover in Madrid for 4h 45m

Sat Sep 27th 2025 Iberia Airlines · IB 6586 Depart at 11:55pm from Madrid (MAD) Fly for 13h 25m Arrive at 8:20am in Santiago de Chile (SCL)
US$2252.50

6:50pm - 8:20am
Fri Sep 26th 2025

17h 30m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Fri Sep 26th 2025 easyJet · U2 6723 Depart at 6:50pm from Lisbon (LIS) Fly for 1h 30m Arrive at 9:20pm in Madrid (MAD)

Layover in Madrid for 2h 35m

Fri Sep 26th 2025 Iberia Airlines · IB 6586 Depart at 11:55pm from Madrid (MAD) Fly for 13h 25m Arrive at 8:20am in Santiago de Chile (SCL)
US$2256.74

7:05pm - 8:20am
Sat Sep 27th 2025

17h 15m
Lisbon (LIS) → Santiago de Chile (SCL)

1 Stop

Sat Sep 27th 2025 TAP Portugal · TP 1020 Depart at 7:05pm from Lisbon (LIS) Fly for 1h 20m Arrive at 9:25pm in Madrid (MAD)

Layover in Madrid for 2h 30m

Sat Sep 27th 2025 Iberia Airlines · IB 6586 Depart at 11:55pm from Madrid (MAD) Fly for 13h 25m Arrive at 8:20am in Santiago de Chile (SCL)

Sarah Belizaire

@sarahbb1

Have flexible travel plans or looking for alternative routes given the chaos? Check out all the connection possibilities via a super helpful site created by @ismaelyws flightlist.io thanks to @andy_travels for the recommendation #travel #flights

John Ford

@eyupitsjohn

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Roaming Sonaa

@roamingsonaa

For people wanting to maximize their trips, Flightlist is my newest travel hack for uncovering the coolest routes at irresistible prices. No stress, no annoying ads — just seamless flight booking with amazing functionality.

Andy Travels

@andy_travels

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Travel With Bender

@travelwitbender

Did you spot my recent article about how to score cheap one way flights? ✈️ FlightList is my new secret tool for discovering cheap routes, within a departure date range. Plus you can also search by country/region for departures & destinations. Powerful! 💪

Wesley Mergard

@travel.with.wes

One useful tool I've found for evaluating different departure and return dates is called FlightList.io. You can quickly scan different travel date ranges, carriers and one way flight options to easily determine the cheapest flight combinations for your trip.

Flights from Lisbon to Santiago (LIS to SCL)

Sarah Belizaire

John Ford

Roaming Sonaa

Andy Travels

Travel With Bender

Wesley Mergard

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