Sun May 14th 2023 Allegiant Air · G4 338 Depart at 8:20pm from Des Moines (DSM) Fly for 1h 40m Arrive at 10:00pm in Nashville (BNA)
Layover in Nashville for 14h 24m
Mon May 15th 2023 Allegiant Air · G4 1965 Depart at 12:24pm from Nashville (BNA) Fly for 2h 17m Arrive at 3:41pm in Key West (EYW)
Sun Mar 5th 2023 Allegiant Air · G4 443 Depart at 10:00am from Des Moines (DSM) Fly for 1h 34m Arrive at 11:34am in Nashville (BNA)
Layover in Nashville for 25h 0m
Mon Mar 6th 2023 Allegiant Air · G4 343 Depart at 12:34pm from Nashville (BNA) Fly for 2h 14m Arrive at 3:48pm in Key West (EYW)
Tue Feb 28th 2023 Allegiant Air · G4 431 Depart at 8:30am from Des Moines (DSM) Fly for 1h 35m Arrive at 10:05am in Nashville (BNA)
Layover in Nashville for 4h 3m
Tue Feb 28th 2023 Allegiant Air · G4 2845 Depart at 2:08pm from Nashville (BNA) Fly for 1h 48m Arrive at 4:56pm in Orlando (SFB)
Layover in Orlando for 15h 4m
Wed Mar 1st 2023 Allegiant Air · G4 1211 Depart at 8:00am from Orlando (SFB) Fly for 1h 11m Arrive at 9:11am in Key West (EYW)
Sun Mar 19th 2023 Allegiant Air · G4 1079 Depart at 6:37pm from Des Moines (DSM) Fly for 2h 38m Arrive at 10:15pm in Tampa (PIE)
Layover in Tampa for 15h 17m
Mon Mar 20th 2023 Allegiant Air · G4 2710 Depart at 1:32pm from Tampa (PIE) Fly for 0h 59m Arrive at 2:31pm in Key West (EYW)
Thu Mar 16th 2023 Allegiant Air · G4 2643 Depart at 6:37pm from Des Moines (DSM) Fly for 2h 38m Arrive at 10:15pm in Tampa (PIE)
Layover in Tampa for 15h 17m
Fri Mar 17th 2023 Allegiant Air · G4 2710 Depart at 1:32pm from Tampa (PIE) Fly for 0h 59m Arrive at 2:31pm in Key West (EYW)
Tue Mar 7th 2023 Allegiant Air · G4 443 Depart at 8:30am from Des Moines (DSM) Fly for 1h 34m Arrive at 10:04am in Nashville (BNA)
Layover in Nashville for 3h 57m
Tue Mar 7th 2023 Allegiant Air · G4 1341 Depart at 2:01pm from Nashville (BNA) Fly for 1h 42m Arrive at 4:43pm in Orlando (SFB)
Layover in Orlando for 15h 17m
Wed Mar 8th 2023 Allegiant Air · G4 1211 Depart at 8:00am from Orlando (SFB) Fly for 1h 11m Arrive at 9:11am in Key West (EYW)
Tue Feb 21st 2023 Allegiant Air · G4 431 Depart at 8:30am from Des Moines (DSM) Fly for 1h 35m Arrive at 10:05am in Nashville (BNA)
Layover in Nashville for 6h 51m
Tue Feb 21st 2023 Allegiant Air · G4 2845 Depart at 4:56pm from Nashville (BNA) Fly for 1h 48m Arrive at 7:44pm in Orlando (SFB)
Layover in Orlando for 12h 16m
Wed Feb 22nd 2023 Allegiant Air · G4 1211 Depart at 8:00am from Orlando (SFB) Fly for 1h 11m Arrive at 9:11am in Key West (EYW)
Mon May 1st 2023 Allegiant Air · G4 459 Depart at 7:30am from Des Moines (DSM) Fly for 2h 44m Arrive at 11:14am in Tampa (PIE)
Layover in Tampa for 2h 15m
Mon May 1st 2023 Allegiant Air · G4 1095 Depart at 1:29pm from Tampa (PIE) Fly for 1h 1m Arrive at 2:30pm in Key West (EYW)
Sun Apr 9th 2023 Allegiant Air · G4 332 Depart at 9:31pm from Des Moines (DSM) Fly for 1h 32m Arrive at 11:03pm in Nashville (BNA)
Layover in Nashville for 13h 29m
Mon Apr 10th 2023 Allegiant Air · G4 343 Depart at 12:32pm from Nashville (BNA) Fly for 2h 12m Arrive at 3:44pm in Key West (EYW)
Sun Mar 5th 2023 Allegiant Air · G4 443 Depart at 10:00am from Des Moines (DSM) Fly for 1h 34m Arrive at 11:34am in Nashville (BNA)
Layover in Nashville for 3h 17m
Sun Mar 5th 2023 Allegiant Air · G4 346 Depart at 2:51pm from Nashville (BNA) Fly for 1h 43m Arrive at 5:34pm in Tampa (PIE)
Layover in Tampa for 19h 58m
Mon Mar 6th 2023 Allegiant Air · G4 2710 Depart at 1:32pm from Tampa (PIE) Fly for 0h 59m Arrive at 2:31pm in Key West (EYW)
Tue Mar 14th 2023 Allegiant Air · G4 469 Depart at 1:16pm from Des Moines (DSM) Fly for 2h 42m Arrive at 4:58pm in Orlando (SFB)
Layover in Orlando for 15h 2m
Wed Mar 15th 2023 Allegiant Air · G4 1211 Depart at 8:00am from Orlando (SFB) Fly for 1h 11m Arrive at 9:11am in Key West (EYW)
Sun May 7th 2023 Allegiant Air · G4 338 Depart at 8:20pm from Des Moines (DSM) Fly for 1h 40m Arrive at 10:00pm in Nashville (BNA)
Layover in Nashville for 14h 24m
Mon May 8th 2023 Allegiant Air · G4 1965 Depart at 12:24pm from Nashville (BNA) Fly for 2h 17m Arrive at 3:41pm in Key West (EYW)
Fri May 19th 2023 Allegiant Air · G4 2068 Depart at 4:05pm from Des Moines (DSM) Fly for 2h 44m Arrive at 7:49pm in Orlando (SFB)
Layover in Orlando for 12h 41m
Sat May 20th 2023 Allegiant Air · G4 2909 Depart at 8:30am from Orlando (SFB) Fly for 1h 8m Arrive at 9:38am in Key West (EYW)
Sun Apr 23rd 2023 Allegiant Air · G4 332 Depart at 8:31pm from Des Moines (DSM) Fly for 1h 32m Arrive at 10:03pm in Nashville (BNA)
Layover in Nashville for 14h 31m
Mon Apr 24th 2023 Allegiant Air · G4 343 Depart at 12:34pm from Nashville (BNA) Fly for 2h 15m Arrive at 3:49pm in Key West (EYW)
Tue Mar 7th 2023 Delta Air Lines · DL 5221 Depart at 5:25pm from Des Moines (DSM) Fly for 1h 28m Arrive at 6:53pm in Minneapolis (MSP)
Layover in Minneapolis for 1h 32m
Tue Mar 7th 2023 Delta Air Lines · DL 2074 Depart at 8:25pm from Minneapolis (MSP) Fly for 1h 42m Arrive at 11:07pm in Indianapolis (IND)
Layover in Indianapolis for 14h 26m
Wed Mar 8th 2023 Allegiant Air · G4 1334 Depart at 1:33pm from Indianapolis (IND) Fly for 2h 44m Arrive at 4:17pm in Key West (EYW)
Tue Feb 28th 2023 Allegiant Air · G4 471 Depart at 1:22pm from Des Moines (DSM) Fly for 2h 45m Arrive at 5:07pm in Orlando (SFB)
Layover in Orlando for 14h 53m
Wed Mar 1st 2023 Allegiant Air · G4 1211 Depart at 8:00am from Orlando (SFB) Fly for 1h 11m Arrive at 9:11am in Key West (EYW)
Tue May 2nd 2023 Frontier Airlines · F9 471 Depart at 8:34pm from Des Moines (DSM) Fly for 2h 7m Arrive at 9:41pm in Denver (DEN)
Layover in Denver for 8h 19m
Wed May 3rd 2023 Frontier Airlines · F9 606 Depart at 6:00am from Denver (DEN) Fly for 2h 33m Arrive at 10:33am in Indianapolis (IND)
Layover in Indianapolis for 2h 58m
Wed May 3rd 2023 Allegiant Air · G4 1305 Depart at 1:31pm from Indianapolis (IND) Fly for 2h 37m Arrive at 4:08pm in Key West (EYW)
Mon Apr 3rd 2023 Allegiant Air · G4 477 Depart at 2:39pm from Des Moines (DSM) Fly for 3h 3m Arrive at 6:42pm in Fort Lauderdale (FLL)
Layover in Fort Lauderdale for 15h 23m
Tue Apr 4th 2023 Silver Airways · 3M 93 Depart at 10:05am from Fort Lauderdale (FLL) Fly for 1h 5m Arrive at 11:10am in Key West (EYW)
Tue Mar 21st 2023 United Airlines · UA 3417 Depart at 6:45pm from Des Moines (DSM) Fly for 1h 26m Arrive at 8:11pm in Chicago (ORD)
Layover in Chicago for 1h 39m
Tue Mar 21st 2023 United Airlines · UA 1773 Depart at 9:50pm from Chicago (ORD) Fly for 1h 4m Arrive at 11:54pm in Indianapolis (IND)
Layover in Indianapolis for 13h 39m
Wed Mar 22nd 2023 Allegiant Air · G4 1334 Depart at 1:33pm from Indianapolis (IND) Fly for 2h 44m Arrive at 4:17pm in Key West (EYW)
Mon Mar 27th 2023 Allegiant Air · G4 477 Depart at 2:39pm from Des Moines (DSM) Fly for 3h 3m Arrive at 6:42pm in Fort Lauderdale (FLL)
Layover in Fort Lauderdale for 15h 23m
Tue Mar 28th 2023 Silver Airways · 3M 93 Depart at 10:05am from Fort Lauderdale (FLL) Fly for 1h 5m Arrive at 11:10am in Key West (EYW)
Sun Mar 19th 2023 Allegiant Air · G4 443 Depart at 6:10am from Des Moines (DSM) Fly for 1h 34m Arrive at 7:44am in Nashville (BNA)
Layover in Nashville for 4h 13m
Sun Mar 19th 2023 Spirit Airlines · NK 2435 Depart at 11:57am from Nashville (BNA) Fly for 1h 56m Arrive at 2:53pm in Orlando (MCO)
Layover in Orlando for 3h 27m
Sun Mar 19th 2023 Silver Airways · 3M 70 Depart at 6:20pm from Orlando (MCO) Fly for 1h 25m Arrive at 7:45pm in Key West (EYW)
Fri Aug 11th 2023 Allegiant Air · G4 475 Depart at 3:09pm from Des Moines (DSM) Fly for 2h 44m Arrive at 6:53pm in Orlando (SFB)
Layover in Orlando for 13h 7m
Sat Aug 12th 2023 Allegiant Air · G4 1320 Depart at 8:00am from Orlando (SFB) Fly for 1h 7m Arrive at 9:07am in Key West (EYW)
Sun Feb 12th 2023 Allegiant Air · G4 344 Depart at 8:54pm from Des Moines (DSM) Fly for 1h 36m Arrive at 10:30pm in Nashville (BNA)
Layover in Nashville for 7h 30m
Mon Feb 13th 2023 Allegiant Air · G4 3406 Depart at 6:00am from Nashville (BNA) Fly for 2h 16m Arrive at 9:16am in Key West (EYW)
Mon Apr 24th 2023 Allegiant Air · G4 459 Depart at 7:30am from Des Moines (DSM) Fly for 2h 44m Arrive at 11:14am in Tampa (PIE)
Layover in Tampa for 2h 15m
Mon Apr 24th 2023 Allegiant Air · G4 1095 Depart at 1:29pm from Tampa (PIE) Fly for 1h 1m Arrive at 2:30pm in Key West (EYW)
Fri Apr 28th 2023 Allegiant Air · G4 459 Depart at 7:30am from Des Moines (DSM) Fly for 2h 44m Arrive at 11:14am in Tampa (PIE)
Layover in Tampa for 2h 15m
Fri Apr 28th 2023 Allegiant Air · G4 1095 Depart at 1:29pm from Tampa (PIE) Fly for 1h 1m Arrive at 2:30pm in Key West (EYW)
Sat Mar 25th 2023 Delta Air Lines · DL 2086 Depart at 5:55pm from Des Moines (DSM) Fly for 2h 8m Arrive at 9:03pm in Atlanta (ATL)
Layover in Atlanta for 1h 22m
Sat Mar 25th 2023 Delta Air Lines · DL 1126 Depart at 10:25pm from Atlanta (ATL) Fly for 1h 29m Arrive at 11:54pm in Tampa (TPA)
Layover in Tampa for 8h 6m
Sun Mar 26th 2023 Silver Airways · 3M 134 Depart at 8:00am from Tampa (TPA) Fly for 1h 15m Arrive at 9:15am in Key West (EYW)
Mon May 15th 2023 Allegiant Air · G4 459 Depart at 7:30am from Des Moines (DSM) Fly for 2h 44m Arrive at 11:14am in Tampa (PIE)
Layover in Tampa for 2h 9m
Mon May 15th 2023 Allegiant Air · G4 987 Depart at 1:23pm from Tampa (PIE) Fly for 1h 1m Arrive at 2:24pm in Key West (EYW)
Mon Mar 20th 2023 Frontier Airlines · F9 1066 Depart at 9:42am from Des Moines (DSM) Fly for 2h 56m Arrive at 1:38pm in Orlando (MCO)
Layover in Orlando for 3h 32m
Mon Mar 20th 2023 Silver Airways · 3M 70 Depart at 5:10pm from Orlando (MCO) Fly for 1h 25m Arrive at 6:35pm in Key West (EYW)
Mon Mar 6th 2023 Frontier Airlines · F9 1066 Depart at 9:41am from Des Moines (DSM) Fly for 2h 59m Arrive at 1:40pm in Orlando (MCO)
Layover in Orlando for 3h 25m
Mon Mar 6th 2023 Silver Airways · 3M 70 Depart at 5:05pm from Orlando (MCO) Fly for 1h 25m Arrive at 6:30pm in Key West (EYW)
Fri Aug 11th 2023 Allegiant Air · G4 467 Depart at 7:30am from Des Moines (DSM) Fly for 3h 13m Arrive at 11:43am in Fort Lauderdale (FLL)
Layover in Fort Lauderdale for 5h 2m
Fri Aug 11th 2023 Silver Airways · 3M 93 Depart at 4:45pm from Fort Lauderdale (FLL) Fly for 1h 5m Arrive at 5:50pm in Key West (EYW)
Fri May 12th 2023 Allegiant Air · G4 459 Depart at 7:30am from Des Moines (DSM) Fly for 2h 44m Arrive at 11:14am in Tampa (PIE)
Layover in Tampa for 2h 9m
Fri May 12th 2023 Allegiant Air · G4 987 Depart at 1:23pm from Tampa (PIE) Fly for 1h 1m Arrive at 2:24pm in Key West (EYW)
Mon Feb 27th 2023 Frontier Airlines · F9 1066 Depart at 9:41am from Des Moines (DSM) Fly for 2h 59m Arrive at 1:40pm in Orlando (MCO)
Layover in Orlando for 3h 25m
Mon Feb 27th 2023 Silver Airways · 3M 70 Depart at 5:05pm from Orlando (MCO) Fly for 1h 25m Arrive at 6:30pm in Key West (EYW)
Fri Jul 28th 2023 Allegiant Air · G4 467 Depart at 7:30am from Des Moines (DSM) Fly for 3h 5m Arrive at 11:35am in Fort Lauderdale (FLL)
Layover in Fort Lauderdale for 5h 10m
Fri Jul 28th 2023 Silver Airways · 3M 93 Depart at 4:45pm from Fort Lauderdale (FLL) Fly for 1h 5m Arrive at 5:50pm in Key West (EYW)
Fri Jun 9th 2023 Allegiant Air · G4 441 Depart at 7:30am from Des Moines (DSM) Fly for 3h 8m Arrive at 11:38am in Fort Lauderdale (FLL)
Layover in Fort Lauderdale for 5h 7m
Fri Jun 9th 2023 Silver Airways · 3M 93 Depart at 4:45pm from Fort Lauderdale (FLL) Fly for 1h 5m Arrive at 5:50pm in Key West (EYW)
Mon Apr 17th 2023 American Airlines · AA 544 Depart at 6:00am from Des Moines (DSM) Fly for 1h 19m Arrive at 7:19am in Chicago (ORD)
Layover in Chicago for 0h 51m
Mon Apr 17th 2023 American Airlines · AA 4380 Depart at 8:10am from Chicago (ORD) Fly for 1h 35m Arrive at 9:45am in Nashville (BNA)
Layover in Nashville for 2h 49m
Mon Apr 17th 2023 Allegiant Air · G4 343 Depart at 12:34pm from Nashville (BNA) Fly for 2h 15m Arrive at 3:49pm in Key West (EYW)
Fri May 5th 2023 Allegiant Air · G4 459 Depart at 7:30am from Des Moines (DSM) Fly for 2h 44m Arrive at 11:14am in Tampa (PIE)
Layover in Tampa for 2h 9m
Fri May 5th 2023 Allegiant Air · G4 987 Depart at 1:23pm from Tampa (PIE) Fly for 1h 1m Arrive at 2:24pm in Key West (EYW)
Mon Apr 17th 2023 Allegiant Air · G4 459 Depart at 7:30am from Des Moines (DSM) Fly for 2h 44m Arrive at 11:14am in Tampa (PIE)
Layover in Tampa for 2h 15m
Mon Apr 17th 2023 Allegiant Air · G4 1095 Depart at 1:29pm from Tampa (PIE) Fly for 1h 1m Arrive at 2:30pm in Key West (EYW)
Sun Mar 5th 2023 American Airlines · AA 544 Depart at 6:00am from Des Moines (DSM) Fly for 1h 19m Arrive at 7:19am in Chicago (ORD)
Layover in Chicago for 0h 56m
Sun Mar 5th 2023 American Airlines · AA 3542 Depart at 8:15am from Chicago (ORD) Fly for 1h 28m Arrive at 10:43am in Pittsburgh (PIT)
Layover in Pittsburgh for 3h 10m
Sun Mar 5th 2023 Allegiant Air · G4 1128 Depart at 1:53pm from Pittsburgh (PIT) Fly for 2h 54m Arrive at 4:47pm in Key West (EYW)
Fri Jun 30th 2023 Allegiant Air · G4 441 Depart at 7:30am from Des Moines (DSM) Fly for 3h 8m Arrive at 11:38am in Fort Lauderdale (FLL)
Layover in Fort Lauderdale for 5h 7m
Fri Jun 30th 2023 Silver Airways · 3M 93 Depart at 4:45pm from Fort Lauderdale (FLL) Fly for 1h 5m Arrive at 5:50pm in Key West (EYW)
Mon May 8th 2023 Allegiant Air · G4 459 Depart at 7:30am from Des Moines (DSM) Fly for 2h 44m Arrive at 11:14am in Tampa (PIE)
Layover in Tampa for 2h 9m
Mon May 8th 2023 Allegiant Air · G4 987 Depart at 1:23pm from Tampa (PIE) Fly for 1h 1m Arrive at 2:24pm in Key West (EYW)
Thu May 11th 2023 Delta Air Lines · DL 2308 Depart at 5:45am from Des Moines (DSM) Fly for 2h 18m Arrive at 9:03am in Atlanta (ATL)
Layover in Atlanta for 0h 37m
Thu May 11th 2023 Delta Air Lines · DL 2972 Depart at 9:40am from Atlanta (ATL) Fly for 1h 54m Arrive at 11:34am in Key West (EYW)
Tue May 16th 2023 Delta Air Lines · DL 2308 Depart at 5:45am from Des Moines (DSM) Fly for 2h 18m Arrive at 9:03am in Atlanta (ATL)
Layover in Atlanta for 0h 37m
Tue May 16th 2023 Delta Air Lines · DL 2972 Depart at 9:40am from Atlanta (ATL) Fly for 1h 54m Arrive at 11:34am in Key West (EYW)
Wed May 24th 2023 Delta Air Lines · DL 2308 Depart at 5:45am from Des Moines (DSM) Fly for 2h 18m Arrive at 9:03am in Atlanta (ATL)
Layover in Atlanta for 0h 37m
Wed May 24th 2023 Delta Air Lines · DL 2972 Depart at 9:40am from Atlanta (ATL) Fly for 1h 54m Arrive at 11:34am in Key West (EYW)
Sat Apr 1st 2023 American Airlines · AA 2189 Depart at 7:16am from Des Moines (DSM) Fly for 2h 14m Arrive at 10:30am in Charlotte (CLT)
Layover in Charlotte for 0h 37m
Sat Apr 1st 2023 American Airlines · AA 2515 Depart at 11:07am from Charlotte (CLT) Fly for 2h 13m Arrive at 1:20pm in Key West (EYW)
Mon May 29th 2023 Delta Air Lines · DL 2308 Depart at 5:45am from Des Moines (DSM) Fly for 2h 18m Arrive at 9:03am in Atlanta (ATL)
Layover in Atlanta for 0h 37m
Mon May 29th 2023 Delta Air Lines · DL 2972 Depart at 9:40am from Atlanta (ATL) Fly for 1h 54m Arrive at 11:34am in Key West (EYW)
Sun Mar 12th 2023 American Airlines · AA 2189 Depart at 7:16am from Des Moines (DSM) Fly for 2h 14m Arrive at 10:30am in Charlotte (CLT)
Layover in Charlotte for 0h 37m
Sun Mar 12th 2023 American Airlines · AA 2515 Depart at 11:07am from Charlotte (CLT) Fly for 2h 13m Arrive at 1:20pm in Key West (EYW)
Wed Mar 29th 2023 American Airlines · AA 2189 Depart at 7:16am from Des Moines (DSM) Fly for 2h 14m Arrive at 10:30am in Charlotte (CLT)
Layover in Charlotte for 0h 37m
Wed Mar 29th 2023 American Airlines · AA 2515 Depart at 11:07am from Charlotte (CLT) Fly for 2h 13m Arrive at 1:20pm in Key West (EYW)
Thu Mar 30th 2023 American Airlines · AA 2189 Depart at 7:16am from Des Moines (DSM) Fly for 2h 14m Arrive at 10:30am in Charlotte (CLT)
Layover in Charlotte for 0h 37m
Thu Mar 30th 2023 American Airlines · AA 2515 Depart at 11:07am from Charlotte (CLT) Fly for 2h 13m Arrive at 1:20pm in Key West (EYW)
Thu Mar 16th 2023 American Airlines · AA 2189 Depart at 7:16am from Des Moines (DSM) Fly for 2h 14m Arrive at 10:30am in Charlotte (CLT)
Layover in Charlotte for 0h 37m
Thu Mar 16th 2023 American Airlines · AA 2515 Depart at 11:07am from Charlotte (CLT) Fly for 2h 13m Arrive at 1:20pm in Key West (EYW)
Sun Mar 5th 2023 American Airlines · AA 2189 Depart at 7:16am from Des Moines (DSM) Fly for 2h 14m Arrive at 10:30am in Charlotte (CLT)
Layover in Charlotte for 0h 37m
Sun Mar 5th 2023 American Airlines · AA 2515 Depart at 11:07am from Charlotte (CLT) Fly for 2h 13m Arrive at 1:20pm in Key West (EYW)
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Tips to help you find the cheapest flights from Des Moines to Key West (DSM to EYW).
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