Flights from Des Moines to Italy (DSM to IT)

Discover more affordable routes and cheaper dates from Des Moines to Italy (DSM to IT) within a date range.

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  • US$926
    United AirlinesUnited Airlines
    8:00am - 1:20pm
    Thu Apr 30th 2026
    22h 20m
    Des Moines (DSM) → Milan (MXP)
    1 Stop

    Thu Apr 30th 2026 United Airlines · UA 1363 Depart at 8:00am from Des Moines (DSM) Fly for 1h 30m Arrive at 9:30am in Chicago (ORD)

    Layover in Chicago for 11h 55m

    Thu Apr 30th 2026 United Airlines · UA 416 Depart at 9:25pm from Chicago (ORD) Fly for 8h 55m Arrive at 1:20pm in Milan (MXP)

  • US$1157
    United AirlinesUnited Airlines
    3:15pm - 1:20pm
    Thu Apr 30th 2026
    15h 5m
    Des Moines (DSM) → Milan (MXP)
    1 Stop

    Thu Apr 30th 2026 United Airlines · UA 1568 Depart at 3:15pm from Des Moines (DSM) Fly for 1h 23m Arrive at 4:38pm in Chicago (ORD)

    Layover in Chicago for 4h 47m

    Thu Apr 30th 2026 United Airlines · UA 416 Depart at 9:25pm from Chicago (ORD) Fly for 8h 55m Arrive at 1:20pm in Milan (MXP)

  • US$1231
    United AirlinesUnited Airlines
    11:30am - 7:55am
    Sun May 3rd 2026
    13h 25m
    Des Moines (DSM) → Rome (FCO)
    1 Stop

    Sun May 3rd 2026 United Airlines · UA 2306 Depart at 11:30am from Des Moines (DSM) Fly for 1h 32m Arrive at 1:02pm in Chicago (ORD)

    Layover in Chicago for 2h 33m

    Sun May 3rd 2026 United Airlines · UA 970 Depart at 3:35pm from Chicago (ORD) Fly for 9h 20m Arrive at 7:55am in Rome (FCO)

  • US$1345
    United AirlinesUnited Airlines
    6:45pm - 1:20pm
    Thu Apr 30th 2026
    11h 35m
    Des Moines (DSM) → Milan (MXP)
    1 Stop

    Thu Apr 30th 2026 United Airlines · UA 3433 Depart at 6:45pm from Des Moines (DSM) Fly for 1h 31m Arrive at 8:16pm in Chicago (ORD)

    Layover in Chicago for 1h 9m

    Thu Apr 30th 2026 United Airlines · UA 416 Depart at 9:25pm from Chicago (ORD) Fly for 8h 55m Arrive at 1:20pm in Milan (MXP)

  • US$1369
    United AirlinesUnited Airlines
    11:30am - 7:55am
    Fri May 1st 2026
    13h 25m
    Des Moines (DSM) → Rome (FCO)
    1 Stop

    Fri May 1st 2026 United Airlines · UA 2306 Depart at 11:30am from Des Moines (DSM) Fly for 1h 32m Arrive at 1:02pm in Chicago (ORD)

    Layover in Chicago for 2h 33m

    Fri May 1st 2026 United Airlines · UA 970 Depart at 3:35pm from Chicago (ORD) Fly for 9h 20m Arrive at 7:55am in Rome (FCO)

  • US$1369
    United AirlinesUnited Airlines
    8:00am - 7:55am
    Fri May 1st 2026
    16h 55m
    Des Moines (DSM) → Rome (FCO)
    1 Stop

    Fri May 1st 2026 United Airlines · UA 1363 Depart at 8:00am from Des Moines (DSM) Fly for 1h 30m Arrive at 9:30am in Chicago (ORD)

    Layover in Chicago for 6h 5m

    Fri May 1st 2026 United Airlines · UA 970 Depart at 3:35pm from Chicago (ORD) Fly for 9h 20m Arrive at 7:55am in Rome (FCO)

  • US$1396
    United AirlinesUnited Airlines
    6:45pm - 7:55am
    Fri May 1st 2026
    30h 10m
    Des Moines (DSM) → Rome (FCO)
    1 Stop

    Fri May 1st 2026 United Airlines · UA 3433 Depart at 6:45pm from Des Moines (DSM) Fly for 1h 31m Arrive at 8:16pm in Chicago (ORD)

    Layover in Chicago for 19h 19m

    Sat May 2nd 2026 United Airlines · UA 970 Depart at 3:35pm from Chicago (ORD) Fly for 9h 20m Arrive at 7:55am in Rome (FCO)

  • US$1582
    United AirlinesUnited Airlines
    1:45pm - 12:20pm
    Fri May 1st 2026
    15h 35m
    Des Moines (DSM) → Rome (FCO)
    1 Stop

    Fri May 1st 2026 United Airlines · UA 2005 Depart at 1:45pm from Des Moines (DSM) Fly for 1h 49m Arrive at 2:34pm in Denver (DEN)

    Layover in Denver for 3h 16m

    Fri May 1st 2026 United Airlines · UA 177 Depart at 5:50pm from Denver (DEN) Fly for 10h 30m Arrive at 12:20pm in Rome (FCO)

  • US$1835
    United AirlinesUnited Airlines
    6:45pm - 7:55am
    Sun May 3rd 2026
    30h 10m
    Des Moines (DSM) → Rome (FCO)
    1 Stop

    Sun May 3rd 2026 United Airlines · UA 3433 Depart at 6:45pm from Des Moines (DSM) Fly for 1h 31m Arrive at 8:16pm in Chicago (ORD)

    Layover in Chicago for 19h 19m

    Mon May 4th 2026 United Airlines · UA 970 Depart at 3:35pm from Chicago (ORD) Fly for 9h 20m Arrive at 7:55am in Rome (FCO)

  • US$8388
    United AirlinesUnited Airlines
    6:45pm - 1:20pm
    Tue May 5th 2026
    11h 35m
    Des Moines (DSM) → Milan (MXP)
    1 Stop

    Tue May 5th 2026 United Airlines · UA 3433 Depart at 6:45pm from Des Moines (DSM) Fly for 1h 31m Arrive at 8:16pm in Chicago (ORD)

    Layover in Chicago for 1h 9m

    Tue May 5th 2026 United Airlines · UA 416 Depart at 9:25pm from Chicago (ORD) Fly for 8h 55m Arrive at 1:20pm in Milan (MXP)

  • US$8605
    United AirlinesUnited Airlines
    6:45pm - 1:20pm
    Mon May 4th 2026
    11h 35m
    Des Moines (DSM) → Milan (MXP)
    1 Stop

    Mon May 4th 2026 United Airlines · UA 3433 Depart at 6:45pm from Des Moines (DSM) Fly for 1h 31m Arrive at 8:16pm in Chicago (ORD)

    Layover in Chicago for 1h 9m

    Mon May 4th 2026 United Airlines · UA 416 Depart at 9:25pm from Chicago (ORD) Fly for 8h 55m Arrive at 1:20pm in Milan (MXP)

@sarahbb1
Sarah Belizaire
@sarahbb1

Have flexible travel plans or looking for alternative routes given the chaos? Check out all the connection possibilities via a super helpful site created by @ismaelyws flightlist.io thanks to @andy_travels for the recommendation #travel #flights

@eyupitsjohn
John Ford
@eyupitsjohn

There seem to be lots of sites launching at the moment that promise to find you cheap flights but not many have the professional finish of Flightlist by @ismaelyws #travel #flights

@oamingsonaa
Roaming Sonaa
@roamingsonaa

For people wanting to maximize their trips, Flightlist is my newest travel hack for uncovering the coolest routes at irresistible prices. No stress, no annoying ads — just seamless flight booking with amazing functionality.

@andy_travels
Andy Travels
@andy_travels

@ismaelyws Just tried out Flightlist for the first time. Really nice idea, well made, and just what I need at the moment 👍

@travelwitbender
Travel With Bender
@travelwitbender

Did you spot my recent article about how to score cheap one way flights? ✈️ FlightList is my new secret tool for discovering cheap routes, within a departure date range. Plus you can also search by country/region for departures & destinations. Powerful! 💪

@travel.with.wes
Wesley Mergard
@travel.with.wes

One useful tool I've found for evaluating different departure and return dates is called FlightList.io. You can quickly scan different travel date ranges, carriers and one way flight options to easily determine the cheapest flight combinations for your trip.

Explore Flight Options

FlightList Blog

Flightlist Interviews 7 Travel Experts On Why They Book One Way Flights
Flightlist Interviews 7 Travel Experts On Why They Book One Way Flights
Why I built FlightList & solved my own problem
Why I Built FlightList & Solved My Own Problem

About FlightList

❝Founded by a remote worker and frequent flyer, who discovered that the best deals come from searching with flexible dates across entire countries or regions. Our streamlined platform strips away the clutter found on typical travel sites, offering a clean interface that focuses solely on finding cost-effective flights. Unlike traditional booking sites, FlightList allows users to search by date ranges and broad destinations, unveiling opportunities that rigid parameters often miss. Our filters let travelers tailor searches to their specific needs, whether they're digital nomads seeking their next adventure or budget-conscious explorers maximizing travel funds. We've made finding cheap flights into a quicker and easier experience, empowering users to discover just how far their budget can take them.❞

Hans Desjarlais, Founder Hans Desjarlais Profile Picture